Radioiodinated meta‐iodobenzylguanidine uptake in medullary thyroid cancer: A French cooperative study

Fifty meta‐iodobenzylguanidine (MIBG) scintiscans were performed in three groups of medullary thyroid cancer (MTC) patients. Group 1 (n = 11) included treated patients with normal calcitonin levels; Group 2 (n = 24) included patients with elevated calcitonin levels due to sporadic and isolated MTC;...

Full description

Saved in:
Bibliographic Details
Published in:Cancer 1987-11, Vol.60 (9), p.2189-2194
Main Authors: Baulieu, Jean‐Louis, Guilloteau, Denis, Delisle, Marie‐Joelle, Perdrisot, Remy, Gardet, Paule, Delépine, Nicole, Baulieu, Françoise, Dupont, Jean‐Louis, Talbot, Jean‐Noël, Coutris, Gerard, Calmettes, Claude
Format: Article
Language:English
Subjects:
3-Iodobenzylguanidine
Adolescent
Adrenal Gland Neoplasms - diagnostic imaging
Adult
Aged
Biological and medical sciences
Calcitonin - blood
Carcinoma - blood
Carcinoma - diagnostic imaging
Carcinoma - genetics
Carcinoma - secondary
Child
Endocrinopathies
Evaluation Studies as Topic
Female
Humans
Iodine Radioisotopes
Iodobenzenes
Lymphatic Metastasis
Male
Malignant tumors
Medical sciences
Middle Aged
Multiple Endocrine Neoplasia - diagnostic imaging
Pheochromocytoma - diagnostic imaging
Radionuclide Imaging
Thyroid Neoplasms - blood
Thyroid Neoplasms - diagnostic imaging
Thyroid Neoplasms - genetics
Thyroid. Thyroid axis (diseases)
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Fifty meta‐iodobenzylguanidine (MIBG) scintiscans were performed in three groups of medullary thyroid cancer (MTC) patients. Group 1 (n = 11) included treated patients with normal calcitonin levels; Group 2 (n = 24) included patients with elevated calcitonin levels due to sporadic and isolated MTC; Group 3 (n = 15) included patients with elevated calcitonin levels due to familial MTC or multiple endocrine neoplasia Type IIA syndrome (MEN). In Group 1 three pheochromocytoma were depicted by MIBG scintiscan. In Group 2 MTC was seen in a small number of patients (3 of 24). In Group 3, besides adrenal hyperplasia and pheochromocytoma four patients, MIBG scintigraphy showed where MTC had localized and spread in almost half of patients (7 of 15). MIBG uptake occurred in patients with relatively high calcitonin level (>0.6 nmol/l). These data indicate that in patients with familial MTC or MEN syndrome, MIBG scintiscan can be useful not only in detecting associated pheochromocytoma, but also in showing MTC.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19871101)60:9<2189::AID-CNCR2820600913>3.0.CO;2-C