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Effects of Sodium 5-Methoxysalicylate on Macromolecule Absorption and Mucosal Morphology in a Vascularly Perfused Rat Gut Preparation In Vivo

The effect of sodium 5-methoxysalicylate on absorption was assessed by measurement of the appearance of test compounds in the portal blood output of a perfused rat gut model. The test compounds were a hexapeptide analogue of somatostatin, insulin, and horseradish peroxidase. Considerable amounts of...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1987-12, Vol.76 (12), p.857-861
Main Authors: Peters, G.E., Hutchinson, L.E.F., Hyde, R., McMartin, C., Metcalfe, S.B.
Format: Article
Language:English
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Summary:The effect of sodium 5-methoxysalicylate on absorption was assessed by measurement of the appearance of test compounds in the portal blood output of a perfused rat gut model. The test compounds were a hexapeptide analogue of somatostatin, insulin, and horseradish peroxidase. Considerable amounts of sodium 5-methoxysalicylate were present in the portal blood 10 min after intraduodenal administration. When co-administered with sodium 5-methoxysalicylate (60 mg), a marked increase in the concentrations of the test substances occurred at t = 15 min which lasted for a further 15 min. Quantities of
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600761202