Infradian rhythms in urinary growth hormone excretion

All studies of urinary GH excretion in normal and disordered growth have revealed marked day to day (infradian) variation. We used serial overnight urinary GH estimations as an indirect measure of endogenous GH secretion in eight normal prepubertal children (aged 3.6-7.3 yr) over 90-365 days to dete...

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Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 1996, Vol.81 (1), p.100-106
Main Authors: THALANGE, N. K. S, GILL, M. S, GILL, L, WHATMORE, A. J, ADDISON, G. M, PRICE, D. A, CLAYTON, P. E
Format: Article
Language:English
Subjects:
Biological and medical sciences
Child
Child, Preschool
Circadian Rhythm
Creatinine - urine
Female
Fundamental and applied biological sciences. Psychology
Growth Hormone - secretion
Growth Hormone - urine
Hormones and neuropeptides. Regulation
Humans
Hypothalamus. Hypophysis. Epiphysis. Urophysis
Male
Vertebrates: endocrinology
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Summary:All studies of urinary GH excretion in normal and disordered growth have revealed marked day to day (infradian) variation. We used serial overnight urinary GH estimations as an indirect measure of endogenous GH secretion in eight normal prepubertal children (aged 3.6-7.3 yr) over 90-365 days to determine whether longer term rhythms in GH output could exist. This study constitutes a first step in examining the potential relationship between GH excretion and growth. Urinary GH was measured by immunoradiometric assay after dialysis, expressed as the total amount excreted (nanograms per night) or as the GH/creatinine ratio (nanograms per mmol), and assessed by pulse counting techniques and time-series analysis. Variability in urinary GH excretion (median coefficient of variation, 46%) was significantly greater than creatinine (median coefficient of variation, 25%; P = 0.003). Additionally, there was marked month by month variation in baseline urinary GH in all children. High frequency pulses of urinary GH were defined in all children, with periods between 3-5 days. In the two children followed for 7 months or more, time-series analysis was also undertaken on urinary GH data divided into weekly series. This revealed significant rhythms present at 2.6 and 4.1 weeks. There were, therefore, three components to urinary GH excretion: long term basal fluctuation (over months), short term pulses (over days), and intermediate rhythms (over weeks). Further work is required to establish the relationship between these patterns of GH excretion and short term growth.
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.81.1.100