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Infradian rhythms in urinary growth hormone excretion
All studies of urinary GH excretion in normal and disordered growth have revealed marked day to day (infradian) variation. We used serial overnight urinary GH estimations as an indirect measure of endogenous GH secretion in eight normal prepubertal children (aged 3.6-7.3 yr) over 90-365 days to dete...
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Published in: | The journal of clinical endocrinology and metabolism 1996, Vol.81 (1), p.100-106 |
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creator | THALANGE, N. K. S GILL, M. S GILL, L WHATMORE, A. J ADDISON, G. M PRICE, D. A CLAYTON, P. E |
description | All studies of urinary GH excretion in normal and disordered growth have revealed marked day to day (infradian) variation. We used serial overnight urinary GH estimations as an indirect measure of endogenous GH secretion in eight normal prepubertal children (aged 3.6-7.3 yr) over 90-365 days to determine whether longer term rhythms in GH output could exist. This study constitutes a first step in examining the potential relationship between GH excretion and growth. Urinary GH was measured by immunoradiometric assay after dialysis, expressed as the total amount excreted (nanograms per night) or as the GH/creatinine ratio (nanograms per mmol), and assessed by pulse counting techniques and time-series analysis. Variability in urinary GH excretion (median coefficient of variation, 46%) was significantly greater than creatinine (median coefficient of variation, 25%; P = 0.003). Additionally, there was marked month by month variation in baseline urinary GH in all children. High frequency pulses of urinary GH were defined in all children, with periods between 3-5 days. In the two children followed for 7 months or more, time-series analysis was also undertaken on urinary GH data divided into weekly series. This revealed significant rhythms present at 2.6 and 4.1 weeks. There were, therefore, three components to urinary GH excretion: long term basal fluctuation (over months), short term pulses (over days), and intermediate rhythms (over weeks). Further work is required to establish the relationship between these patterns of GH excretion and short term growth. |
doi_str_mv | 10.1210/jc.81.1.100 |
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Variability in urinary GH excretion (median coefficient of variation, 46%) was significantly greater than creatinine (median coefficient of variation, 25%; P = 0.003). Additionally, there was marked month by month variation in baseline urinary GH in all children. High frequency pulses of urinary GH were defined in all children, with periods between 3-5 days. In the two children followed for 7 months or more, time-series analysis was also undertaken on urinary GH data divided into weekly series. This revealed significant rhythms present at 2.6 and 4.1 weeks. There were, therefore, three components to urinary GH excretion: long term basal fluctuation (over months), short term pulses (over days), and intermediate rhythms (over weeks). Further work is required to establish the relationship between these patterns of GH excretion and short term growth.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.81.1.100</identifier><identifier>PMID: 8550735</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Biological and medical sciences ; Child ; Child, Preschool ; Circadian Rhythm ; Creatinine - urine ; Female ; Fundamental and applied biological sciences. Psychology ; Growth Hormone - secretion ; Growth Hormone - urine ; Hormones and neuropeptides. Regulation ; Humans ; Hypothalamus. Hypophysis. Epiphysis. 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S</creatorcontrib><creatorcontrib>GILL, L</creatorcontrib><creatorcontrib>WHATMORE, A. J</creatorcontrib><creatorcontrib>ADDISON, G. M</creatorcontrib><creatorcontrib>PRICE, D. A</creatorcontrib><creatorcontrib>CLAYTON, P. E</creatorcontrib><title>Infradian rhythms in urinary growth hormone excretion</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>All studies of urinary GH excretion in normal and disordered growth have revealed marked day to day (infradian) variation. We used serial overnight urinary GH estimations as an indirect measure of endogenous GH secretion in eight normal prepubertal children (aged 3.6-7.3 yr) over 90-365 days to determine whether longer term rhythms in GH output could exist. This study constitutes a first step in examining the potential relationship between GH excretion and growth. Urinary GH was measured by immunoradiometric assay after dialysis, expressed as the total amount excreted (nanograms per night) or as the GH/creatinine ratio (nanograms per mmol), and assessed by pulse counting techniques and time-series analysis. Variability in urinary GH excretion (median coefficient of variation, 46%) was significantly greater than creatinine (median coefficient of variation, 25%; P = 0.003). Additionally, there was marked month by month variation in baseline urinary GH in all children. High frequency pulses of urinary GH were defined in all children, with periods between 3-5 days. In the two children followed for 7 months or more, time-series analysis was also undertaken on urinary GH data divided into weekly series. This revealed significant rhythms present at 2.6 and 4.1 weeks. There were, therefore, three components to urinary GH excretion: long term basal fluctuation (over months), short term pulses (over days), and intermediate rhythms (over weeks). Further work is required to establish the relationship between these patterns of GH excretion and short term growth.</description><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Circadian Rhythm</subject><subject>Creatinine - urine</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Growth Hormone - secretion</subject><subject>Growth Hormone - urine</subject><subject>Hormones and neuropeptides. Regulation</subject><subject>Humans</subject><subject>Hypothalamus. Hypophysis. Epiphysis. Urophysis</subject><subject>Male</subject><subject>Vertebrates: endocrinology</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNo9kM1Lw0AQxRdRaq2ePAs5iBdJncnuZpOjFD8KBS8K3pbtZmNSkk3dTbD9793SUN7AHN5vZphHyC3CHBOEp42eZzgPAjgjU8wZjwXm4pxMARKMc5F8X5Ir7zcAyBinEzLJOAdB-ZTwpS2dKmplI1ft-6r1UW2jwdVWuX3047q_voqqzrWdNZHZaWf6urPX5KJUjTc3Y5-Rr9eXz8V7vPp4Wy6eV7GmIu9jXpiCMwzHGC9EqLXOUCEymrKCUyVKpLAuURTasCyjKuWJMSmyUtPDIJ2Rh-Peret-B-N72dZem6ZR1nSDl0LkKWXZAXw8gtp13jtTyq2r2_CCRJCHkORGywxlEECg78a1w7o1xYkdUwn-_egrr1UTArK69icsyXkCkNN_NQduBg</recordid><startdate>1996</startdate><enddate>1996</enddate><creator>THALANGE, N. K. S</creator><creator>GILL, M. S</creator><creator>GILL, L</creator><creator>WHATMORE, A. J</creator><creator>ADDISON, G. M</creator><creator>PRICE, D. A</creator><creator>CLAYTON, P. 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Psychology</topic><topic>Growth Hormone - secretion</topic><topic>Growth Hormone - urine</topic><topic>Hormones and neuropeptides. Regulation</topic><topic>Humans</topic><topic>Hypothalamus. Hypophysis. Epiphysis. Urophysis</topic><topic>Male</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>THALANGE, N. K. S</creatorcontrib><creatorcontrib>GILL, M. S</creatorcontrib><creatorcontrib>GILL, L</creatorcontrib><creatorcontrib>WHATMORE, A. J</creatorcontrib><creatorcontrib>ADDISON, G. M</creatorcontrib><creatorcontrib>PRICE, D. A</creatorcontrib><creatorcontrib>CLAYTON, P. 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E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Infradian rhythms in urinary growth hormone excretion</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>1996</date><risdate>1996</risdate><volume>81</volume><issue>1</issue><spage>100</spage><epage>106</epage><pages>100-106</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>All studies of urinary GH excretion in normal and disordered growth have revealed marked day to day (infradian) variation. We used serial overnight urinary GH estimations as an indirect measure of endogenous GH secretion in eight normal prepubertal children (aged 3.6-7.3 yr) over 90-365 days to determine whether longer term rhythms in GH output could exist. This study constitutes a first step in examining the potential relationship between GH excretion and growth. Urinary GH was measured by immunoradiometric assay after dialysis, expressed as the total amount excreted (nanograms per night) or as the GH/creatinine ratio (nanograms per mmol), and assessed by pulse counting techniques and time-series analysis. Variability in urinary GH excretion (median coefficient of variation, 46%) was significantly greater than creatinine (median coefficient of variation, 25%; P = 0.003). Additionally, there was marked month by month variation in baseline urinary GH in all children. High frequency pulses of urinary GH were defined in all children, with periods between 3-5 days. In the two children followed for 7 months or more, time-series analysis was also undertaken on urinary GH data divided into weekly series. This revealed significant rhythms present at 2.6 and 4.1 weeks. There were, therefore, three components to urinary GH excretion: long term basal fluctuation (over months), short term pulses (over days), and intermediate rhythms (over weeks). Further work is required to establish the relationship between these patterns of GH excretion and short term growth.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>8550735</pmid><doi>10.1210/jc.81.1.100</doi><tpages>7</tpages></addata></record> |
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subjects | Biological and medical sciences Child Child, Preschool Circadian Rhythm Creatinine - urine Female Fundamental and applied biological sciences. Psychology Growth Hormone - secretion Growth Hormone - urine Hormones and neuropeptides. Regulation Humans Hypothalamus. Hypophysis. Epiphysis. Urophysis Male Vertebrates: endocrinology |
title | Infradian rhythms in urinary growth hormone excretion |
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