Similarity Among the Drosophila (6-4) Photolyase, a Human Photolyase Homolog, and the DNA Photolyase-Blue-Light Photoreceptor Family

Ultraviolet light (UV)-induced DNA damage can be repaired by DNA photolyase in a light-dependent manner. Two types of photolyase are known, one specific for cyclobutane pyrimidine dimers (CPD photolyase) and another specific for pyrimidine (6-4) pyrimidone photoproducts [(6-4)photolyase]. In contras...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1996-04, Vol.272 (5258), p.109-112
Main Authors: Todo, Takeshi, Ryo, Haruko, Yamamoto, Kazuo, Toh, Hiroyuki, Inui, Taiichiro, Ayaki, Hitoshi, Nomura, Taisei, Ikenaga, Mituo
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Amino acids
Animals
Brain
Cephalopelvic disproportion
Cloning, Molecular
Complementary DNA
Deoxyribodipyrimidine Photo-Lyase - chemistry
Deoxyribodipyrimidine Photo-Lyase - genetics
Deoxyribodipyrimidine Photo-Lyase - metabolism
Deoxyribonucleic acid
DNA
DNA damage
DNA probes
DNA Repair
DNA, Complementary - genetics
Drosophila
Drosophila melanogaster
Drosophila melanogaster - enzymology
Drosophila melanogaster - genetics
Energy
Enzyme structure-activity relationships
Enzymes
Flavin-Adenine Dinucleotide - metabolism
Genes, Insect
Genetics
Humans
Insects
Libraries
Light
Molecular Sequence Data
Photochemical research
Photoreceptor Cells, Invertebrate - chemistry
Photoreceptors
Plant Proteins - chemistry
Plasmids
Recombinant proteins
Recombinant Proteins - chemistry
Recombinant Proteins - metabolism
Sequence Alignment
Structure-activity relationship
Transcripts (Written Records)
Ultraviolet radiation
Ultraviolet Rays
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Summary:Ultraviolet light (UV)-induced DNA damage can be repaired by DNA photolyase in a light-dependent manner. Two types of photolyase are known, one specific for cyclobutane pyrimidine dimers (CPD photolyase) and another specific for pyrimidine (6-4) pyrimidone photoproducts [(6-4)photolyase]. In contrast to the CPD photolyase, which has been detected in a wide variety of organisms, the (6-4)photolyase has been found only in Drosophila melanogaster. In the present study a gene encoding the Drosophila (6-4)photolyase was cloned, and the deduced amino acid sequence of the product was found to be similar to the CPD photolyase and to the blue-light photoreceptor of plants. A homolog of the Drosophila (6-4)photolyase gene was also cloned from human cells.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.272.5258.109