Loading…
IL-1 β and TNF-α produced by peripheral blood mononuclear cells before and during interferon therapy in patients with chronic hepatitis C
We investigated the spontaneous and phytohemagglutinin-stimulated production of interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) by peripheral blood mononuclear cells in patients with chronic hepatitis C during treatment with interferon-alpha (IFN-alpha). Spontaneous produc...
Saved in:
| Published in: | Digestive diseases and sciences 1996-02, Vol.41 (2), p.315-321 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c311t-d2a40151dbbbb88be36dbb06cd2384ad344e18ad8c6265f5cd48f51045dd5ba93 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c311t-d2a40151dbbbb88be36dbb06cd2384ad344e18ad8c6265f5cd48f51045dd5ba93 |
| container_end_page | 321 |
| container_issue | 2 |
| container_start_page | 315 |
| container_title | Digestive diseases and sciences |
| container_volume | 41 |
| creator | KISHIHARA, Y HAYASHI, J YOSHIMURA, E YAMAJI, K NAKASHIMA, K KASHIWAGI, S |
| description | We investigated the spontaneous and phytohemagglutinin-stimulated production of interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) by peripheral blood mononuclear cells in patients with chronic hepatitis C during treatment with interferon-alpha (IFN-alpha). Spontaneous productions of these were significantly higher in patients with chronic hepatitis C than in healthy subjects. For patients prescribed interferon, stimulated production of TNF-alpha was significantly higher in complete responders than in partial responders, but the differences were small between the other cytokine levels and outcome of IFN treatment. Spontaneous production of these cytokines was higher in patients with genotype III with complete response than in genotype III patients with a partial response, but this was not the case in patients with genotype II. There was a negative correlation between these cytokines and histological activity index. Spontaneous production of cytokines was decreased only in complete responders after the administration of interferon. These data suggest that the elevated production of cytokines in patients with chronic hepatitis C may be due to host response to the virus, and monitoring cytokines along with alanine aminotransferase and hepatitis C virus RNA during treatment may provide more precise information of the effectiveness of therapy. |
| doi_str_mv | 10.1007/BF02093821 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77966020</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>77966020</sourcerecordid><originalsourceid>FETCH-LOGICAL-c311t-d2a40151dbbbb88be36dbb06cd2384ad344e18ad8c6265f5cd48f51045dd5ba93</originalsourceid><addsrcrecordid>eNpFkMFu1DAQhi1U1G4LF-6VfKg4VAp44thxjmXFQqVVeynnyLEnrFHWTu1EaJ-Bp6EPss-El67auXg0_ze_PD8hH4B9Asbqz19WrGQNVyW8IQsQNS9KIdUJWTCQuQeQZ-Q8pV-MsaYGeUpOlWTAa7Egf27XBdD9E9Xe0oe7VbH_S8cY7GzQ0m5HR4xu3GDUA-2GECzdBh_8bAbUkRochkQ77EPE_wZ2js7_pM5PGHuMwdPpsDvu8oiOenLop0R_u2lDzSbLztANHuaTS3T5jrzt9ZDw_fG9ID9WXx-W34v1_bfb5c26MBxgKmypKwYCbJdLqQ65zC2TxpZcVdryqkJQ2iojSyl6YWylegGsEtaKTjf8gnx89s2HPs6Ypnbr0uEW7THMqa3rRsqcaAavn0ETQ0oR-3aMbqvjrgXWHpJvX5PP8OXRde62aF_QY9RZvzrqOhk99FF749ILxln-IDT8H1cDjWY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77966020</pqid></control><display><type>article</type><title>IL-1 β and TNF-α produced by peripheral blood mononuclear cells before and during interferon therapy in patients with chronic hepatitis C</title><source>Springer バックファイル</source><creator>KISHIHARA, Y ; HAYASHI, J ; YOSHIMURA, E ; YAMAJI, K ; NAKASHIMA, K ; KASHIWAGI, S</creator><creatorcontrib>KISHIHARA, Y ; HAYASHI, J ; YOSHIMURA, E ; YAMAJI, K ; NAKASHIMA, K ; KASHIWAGI, S</creatorcontrib><description>We investigated the spontaneous and phytohemagglutinin-stimulated production of interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) by peripheral blood mononuclear cells in patients with chronic hepatitis C during treatment with interferon-alpha (IFN-alpha). Spontaneous productions of these were significantly higher in patients with chronic hepatitis C than in healthy subjects. For patients prescribed interferon, stimulated production of TNF-alpha was significantly higher in complete responders than in partial responders, but the differences were small between the other cytokine levels and outcome of IFN treatment. Spontaneous production of these cytokines was higher in patients with genotype III with complete response than in genotype III patients with a partial response, but this was not the case in patients with genotype II. There was a negative correlation between these cytokines and histological activity index. Spontaneous production of cytokines was decreased only in complete responders after the administration of interferon. These data suggest that the elevated production of cytokines in patients with chronic hepatitis C may be due to host response to the virus, and monitoring cytokines along with alanine aminotransferase and hepatitis C virus RNA during treatment may provide more precise information of the effectiveness of therapy.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/BF02093821</identifier><identifier>PMID: 8601375</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Chronic Disease ; Female ; Hepacivirus - genetics ; Hepatitis C - blood ; Hepatitis C - therapy ; Human viral diseases ; Humans ; Infectious diseases ; Interferon-alpha - therapeutic use ; Interleukin-1 - blood ; Interleukin-1 - metabolism ; Leukocytes, Mononuclear - metabolism ; Male ; Medical sciences ; Middle Aged ; Molecular Sequence Data ; RNA, Viral - blood ; Tumor Necrosis Factor-alpha - metabolism ; Viral diseases ; Viral hepatitis</subject><ispartof>Digestive diseases and sciences, 1996-02, Vol.41 (2), p.315-321</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-d2a40151dbbbb88be36dbb06cd2384ad344e18ad8c6265f5cd48f51045dd5ba93</citedby><cites>FETCH-LOGICAL-c311t-d2a40151dbbbb88be36dbb06cd2384ad344e18ad8c6265f5cd48f51045dd5ba93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,778,782,787,788,23917,23918,25127,27911,27912</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3004519$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8601375$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KISHIHARA, Y</creatorcontrib><creatorcontrib>HAYASHI, J</creatorcontrib><creatorcontrib>YOSHIMURA, E</creatorcontrib><creatorcontrib>YAMAJI, K</creatorcontrib><creatorcontrib>NAKASHIMA, K</creatorcontrib><creatorcontrib>KASHIWAGI, S</creatorcontrib><title>IL-1 β and TNF-α produced by peripheral blood mononuclear cells before and during interferon therapy in patients with chronic hepatitis C</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><description>We investigated the spontaneous and phytohemagglutinin-stimulated production of interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) by peripheral blood mononuclear cells in patients with chronic hepatitis C during treatment with interferon-alpha (IFN-alpha). Spontaneous productions of these were significantly higher in patients with chronic hepatitis C than in healthy subjects. For patients prescribed interferon, stimulated production of TNF-alpha was significantly higher in complete responders than in partial responders, but the differences were small between the other cytokine levels and outcome of IFN treatment. Spontaneous production of these cytokines was higher in patients with genotype III with complete response than in genotype III patients with a partial response, but this was not the case in patients with genotype II. There was a negative correlation between these cytokines and histological activity index. Spontaneous production of cytokines was decreased only in complete responders after the administration of interferon. These data suggest that the elevated production of cytokines in patients with chronic hepatitis C may be due to host response to the virus, and monitoring cytokines along with alanine aminotransferase and hepatitis C virus RNA during treatment may provide more precise information of the effectiveness of therapy.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>Female</subject><subject>Hepacivirus - genetics</subject><subject>Hepatitis C - blood</subject><subject>Hepatitis C - therapy</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Interferon-alpha - therapeutic use</subject><subject>Interleukin-1 - blood</subject><subject>Interleukin-1 - metabolism</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular Sequence Data</subject><subject>RNA, Viral - blood</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNpFkMFu1DAQhi1U1G4LF-6VfKg4VAp44thxjmXFQqVVeynnyLEnrFHWTu1EaJ-Bp6EPss-El67auXg0_ze_PD8hH4B9Asbqz19WrGQNVyW8IQsQNS9KIdUJWTCQuQeQZ-Q8pV-MsaYGeUpOlWTAa7Egf27XBdD9E9Xe0oe7VbH_S8cY7GzQ0m5HR4xu3GDUA-2GECzdBh_8bAbUkRochkQ77EPE_wZ2js7_pM5PGHuMwdPpsDvu8oiOenLop0R_u2lDzSbLztANHuaTS3T5jrzt9ZDw_fG9ID9WXx-W34v1_bfb5c26MBxgKmypKwYCbJdLqQ65zC2TxpZcVdryqkJQ2iojSyl6YWylegGsEtaKTjf8gnx89s2HPs6Ypnbr0uEW7THMqa3rRsqcaAavn0ETQ0oR-3aMbqvjrgXWHpJvX5PP8OXRde62aF_QY9RZvzrqOhk99FF749ILxln-IDT8H1cDjWY</recordid><startdate>19960201</startdate><enddate>19960201</enddate><creator>KISHIHARA, Y</creator><creator>HAYASHI, J</creator><creator>YOSHIMURA, E</creator><creator>YAMAJI, K</creator><creator>NAKASHIMA, K</creator><creator>KASHIWAGI, S</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960201</creationdate><title>IL-1 β and TNF-α produced by peripheral blood mononuclear cells before and during interferon therapy in patients with chronic hepatitis C</title><author>KISHIHARA, Y ; HAYASHI, J ; YOSHIMURA, E ; YAMAJI, K ; NAKASHIMA, K ; KASHIWAGI, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-d2a40151dbbbb88be36dbb06cd2384ad344e18ad8c6265f5cd48f51045dd5ba93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Chronic Disease</topic><topic>Female</topic><topic>Hepacivirus - genetics</topic><topic>Hepatitis C - blood</topic><topic>Hepatitis C - therapy</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Interferon-alpha - therapeutic use</topic><topic>Interleukin-1 - blood</topic><topic>Interleukin-1 - metabolism</topic><topic>Leukocytes, Mononuclear - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Molecular Sequence Data</topic><topic>RNA, Viral - blood</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KISHIHARA, Y</creatorcontrib><creatorcontrib>HAYASHI, J</creatorcontrib><creatorcontrib>YOSHIMURA, E</creatorcontrib><creatorcontrib>YAMAJI, K</creatorcontrib><creatorcontrib>NAKASHIMA, K</creatorcontrib><creatorcontrib>KASHIWAGI, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KISHIHARA, Y</au><au>HAYASHI, J</au><au>YOSHIMURA, E</au><au>YAMAJI, K</au><au>NAKASHIMA, K</au><au>KASHIWAGI, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IL-1 β and TNF-α produced by peripheral blood mononuclear cells before and during interferon therapy in patients with chronic hepatitis C</atitle><jtitle>Digestive diseases and sciences</jtitle><addtitle>Dig Dis Sci</addtitle><date>1996-02-01</date><risdate>1996</risdate><volume>41</volume><issue>2</issue><spage>315</spage><epage>321</epage><pages>315-321</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>We investigated the spontaneous and phytohemagglutinin-stimulated production of interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) by peripheral blood mononuclear cells in patients with chronic hepatitis C during treatment with interferon-alpha (IFN-alpha). Spontaneous productions of these were significantly higher in patients with chronic hepatitis C than in healthy subjects. For patients prescribed interferon, stimulated production of TNF-alpha was significantly higher in complete responders than in partial responders, but the differences were small between the other cytokine levels and outcome of IFN treatment. Spontaneous production of these cytokines was higher in patients with genotype III with complete response than in genotype III patients with a partial response, but this was not the case in patients with genotype II. There was a negative correlation between these cytokines and histological activity index. Spontaneous production of cytokines was decreased only in complete responders after the administration of interferon. These data suggest that the elevated production of cytokines in patients with chronic hepatitis C may be due to host response to the virus, and monitoring cytokines along with alanine aminotransferase and hepatitis C virus RNA during treatment may provide more precise information of the effectiveness of therapy.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>8601375</pmid><doi>10.1007/BF02093821</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-2116 |
| ispartof | Digestive diseases and sciences, 1996-02, Vol.41 (2), p.315-321 |
| issn | 0163-2116 1573-2568 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77966020 |
| source | Springer バックファイル |
| subjects | Adult Aged Biological and medical sciences Chronic Disease Female Hepacivirus - genetics Hepatitis C - blood Hepatitis C - therapy Human viral diseases Humans Infectious diseases Interferon-alpha - therapeutic use Interleukin-1 - blood Interleukin-1 - metabolism Leukocytes, Mononuclear - metabolism Male Medical sciences Middle Aged Molecular Sequence Data RNA, Viral - blood Tumor Necrosis Factor-alpha - metabolism Viral diseases Viral hepatitis |
| title | IL-1 β and TNF-α produced by peripheral blood mononuclear cells before and during interferon therapy in patients with chronic hepatitis C |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T13%3A28%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=IL-1%20%CE%B2%20and%20TNF-%CE%B1%20produced%20by%20peripheral%20blood%20mononuclear%20cells%20before%20and%20during%20interferon%20therapy%20in%20patients%20with%20chronic%20hepatitis%20C&rft.jtitle=Digestive%20diseases%20and%20sciences&rft.au=KISHIHARA,%20Y&rft.date=1996-02-01&rft.volume=41&rft.issue=2&rft.spage=315&rft.epage=321&rft.pages=315-321&rft.issn=0163-2116&rft.eissn=1573-2568&rft.coden=DDSCDJ&rft_id=info:doi/10.1007/BF02093821&rft_dat=%3Cproquest_cross%3E77966020%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c311t-d2a40151dbbbb88be36dbb06cd2384ad344e18ad8c6265f5cd48f51045dd5ba93%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=77966020&rft_id=info:pmid/8601375&rfr_iscdi=true |