Re: How Does the MRP/GS-X Pump Export Doxorubicin?

Broxterman and others comment on the role that the multidrug resistance protein/glutathione S-conjugates play in the transport of the cationic lipophilic drug doxorubicin. Ishikawa and others offer a response.

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1996-04, Vol.88 (7), p.466-467
Main Authors: BROXTERMAN, HENK J., HEIJN, MARC, LANKELMA, JAN
Format: Article
Language:English
Subjects:
Animals
Anion Transport Proteins
Antibiotics, Antineoplastic - metabolism
Antineoplastic Agents - therapeutic use
ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism
Cancer
Carrier Proteins - genetics
Carrier Proteins - metabolism
Cell Line
Doxorubicin - metabolism
Drug resistance
Drug Resistance, Multiple
Drug Resistance, Neoplasm
Drug therapy
Glutathione Transferase - metabolism
Humans
Letters to the editor
Liver - metabolism
Neoplasms - drug therapy
Neoplasms - metabolism
Rats
Recombinant Fusion Proteins - metabolism
Transfection
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Description
Summary:Broxterman and others comment on the role that the multidrug resistance protein/glutathione S-conjugates play in the transport of the cationic lipophilic drug doxorubicin. Ishikawa and others offer a response.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/88.7.466