Urate changes in lean and obese boys during pubertal development

Uric acid metabolism is not uniform throughout puberty. Serum urate increases progressively in obese boys as puberty advances, but it increases significantly only at the end of puberty in lean subjects. Urate filtered per unit of body weight increases in all subjects at the end of puberty when fract...

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Bibliographic Details
Published in:Metabolism, clinical and experimental clinical and experimental, 1996-02, Vol.45 (2), p.203-205
Main Author: Garbagnati, Ersilia
Format: Article
Language:English
Subjects:
ACIDE URIQUE
ACIDO URICO
Adolescent
BODY LEAN MASS
Case-Control Studies
Child
CHILDREN
Cross-Sectional Studies
ENFANT
EXCRECION
EXCRETION
Homeostasis
Humans
Kidney - metabolism
MADUREZ SEXUAL
Male
MATURITE SEXUELLE
METABOLISM
METABOLISME
METABOLISMO
NINOS
Obesity - metabolism
OVERWEIGHT
PESO
POIDS
PUBERTY
Puberty - metabolism
Sex Factors
SEXUAL MATURITY
SOBREPESO
SURPOIDS
URIC ACID
Uric Acid - blood
Uric Acid - metabolism
Uric Acid - urine
WEIGHT
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Summary:Uric acid metabolism is not uniform throughout puberty. Serum urate increases progressively in obese boys as puberty advances, but it increases significantly only at the end of puberty in lean subjects. Urate filtered per unit of body weight increases in all subjects at the end of puberty when fractional excretion is diminished. Urate clearance decreases at the beginning of puberty in obese boys and at the end of puberty in lean subjects. Urate excretion corrected for body weight and the urinary uric acid to creatinine ratio do not change over the course of pubertal development in both lean and obese boys. These results suggest the following hypotheses: (1) renal retention of urate may represent the first mechanism by which uricemia is enhanced at puberty; (2) the kidney may finely modulate serum uric acid concentration through different mechanisms of urate handling, presumably occurring at different tubular sites; and (3) obesity may evoke sooner the urate changes that in lean boys are observed at the end of puberty.
ISSN:0026-0495
1532-8600
DOI:10.1016/S0026-0495(96)90054-2