Augmented expression of obese ( ob) gene during the process of obesity in genetically obese-hyperglycemic Wistar fatty ( falfa) rats

Expression of the obese ( ob) gene is up-regulated in the adipose tissue in several obese rodent models. To study the regulation of the ob gene expression during the development of obesity, we examined the ob gene expression in genetically obese-hyperglycemic Wistar fatty ( falfa) rats at several st...

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Bibliographic Details
Published in:FEBS letters 1996-01, Vol.378 (3), p.267-271
Main Authors: Masuzaki, Hiroaki, Hosoda, Kiminori, Ogawa, Yoshihiro, Shigemoto, Michika, Satoh, Noriko, Mori, Kiyoshi, Tamura, Naohisa, Nishi, Shigeo, Yoshimasa, Yasunao, Yamori, Yukio, Nakao, Kazuwa
Format: Article
Language:English
Subjects:
Adipose Tissue - chemistry
Age Factors
Animals
Body Weight
Disease Models, Animal
Gene Expression
Hyperglycemia - complications
Hyperglycemia - genetics
Leptin
Lipoprotein Lipase - genetics
Male
obese ( ob) gene
Obese rodent models
Obesity - complications
Obesity - genetics
Obesity-linked regulation
Proteins - genetics
Rats
Rats, Wistar
RNA, Messenger - analysis
Tissue Distribution
Wistar fatty ( falfa) rat
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Summary:Expression of the obese ( ob) gene is up-regulated in the adipose tissue in several obese rodent models. To study the regulation of the ob gene expression during the development of obesity, we examined the ob gene expression in genetically obese-hyperglycemic Wistar fatty ( falfa) rats at several stages of obesity. The ob mRNA levels in the adipose tissue from Wistar fatty rats was unequivocally augmented and continued to rise in the process of obesity. Furthermore, the ob gene expression in this obese model was much more rapidly enhanced in the mesenteric fat than in the subcutaneous fat. Moreover, the ob gene expression was more greatly augmented in the mesenteric fat than the lipoprotein lipase gene expression. These results suggest the presence of obesity-linked and region-specific regulation of the ob gene expression.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(95)01472-1