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Augmented expression of obese ( ob) gene during the process of obesity in genetically obese-hyperglycemic Wistar fatty ( falfa) rats
Expression of the obese ( ob) gene is up-regulated in the adipose tissue in several obese rodent models. To study the regulation of the ob gene expression during the development of obesity, we examined the ob gene expression in genetically obese-hyperglycemic Wistar fatty ( falfa) rats at several st...
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| Published in: | FEBS letters 1996-01, Vol.378 (3), p.267-271 |
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| Main Authors: | , , , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c4991-2502f88f05ae6c8c3052fb4c781316521e19c9348a6079e4dbff41557d9fde543 |
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| cites | cdi_FETCH-LOGICAL-c4991-2502f88f05ae6c8c3052fb4c781316521e19c9348a6079e4dbff41557d9fde543 |
| container_end_page | 271 |
| container_issue | 3 |
| container_start_page | 267 |
| container_title | FEBS letters |
| container_volume | 378 |
| creator | Masuzaki, Hiroaki Hosoda, Kiminori Ogawa, Yoshihiro Shigemoto, Michika Satoh, Noriko Mori, Kiyoshi Tamura, Naohisa Nishi, Shigeo Yoshimasa, Yasunao Yamori, Yukio Nakao, Kazuwa |
| description | Expression of the
obese (
ob) gene is up-regulated in the adipose tissue in several obese rodent models. To study the regulation of the
ob gene expression during the development of obesity, we examined the
ob gene expression in genetically obese-hyperglycemic Wistar fatty (
falfa) rats at several stages of obesity. The
ob mRNA levels in the adipose tissue from Wistar fatty rats was unequivocally augmented and continued to rise in the process of obesity. Furthermore, the
ob gene expression in this obese model was much more rapidly enhanced in the mesenteric fat than in the subcutaneous fat. Moreover, the
ob gene expression was more greatly augmented in the mesenteric fat than the lipoprotein lipase gene expression. These results suggest the presence of obesity-linked and region-specific regulation of the
ob gene expression. |
| doi_str_mv | 10.1016/0014-5793(95)01472-1 |
| format | article |
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obese (
ob) gene is up-regulated in the adipose tissue in several obese rodent models. To study the regulation of the
ob gene expression during the development of obesity, we examined the
ob gene expression in genetically obese-hyperglycemic Wistar fatty (
falfa) rats at several stages of obesity. The
ob mRNA levels in the adipose tissue from Wistar fatty rats was unequivocally augmented and continued to rise in the process of obesity. Furthermore, the
ob gene expression in this obese model was much more rapidly enhanced in the mesenteric fat than in the subcutaneous fat. Moreover, the
ob gene expression was more greatly augmented in the mesenteric fat than the lipoprotein lipase gene expression. These results suggest the presence of obesity-linked and region-specific regulation of the
ob gene expression.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/0014-5793(95)01472-1</identifier><identifier>PMID: 8557115</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Adipose Tissue - chemistry ; Age Factors ; Animals ; Body Weight ; Disease Models, Animal ; Gene Expression ; Hyperglycemia - complications ; Hyperglycemia - genetics ; Leptin ; Lipoprotein Lipase - genetics ; Male ; obese ( ob) gene ; Obese rodent models ; Obesity - complications ; Obesity - genetics ; Obesity-linked regulation ; Proteins - genetics ; Rats ; Rats, Wistar ; RNA, Messenger - analysis ; Tissue Distribution ; Wistar fatty ( falfa) rat</subject><ispartof>FEBS letters, 1996-01, Vol.378 (3), p.267-271</ispartof><rights>1996</rights><rights>FEBS Letters 378 (1996) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4991-2502f88f05ae6c8c3052fb4c781316521e19c9348a6079e4dbff41557d9fde543</citedby><cites>FETCH-LOGICAL-c4991-2502f88f05ae6c8c3052fb4c781316521e19c9348a6079e4dbff41557d9fde543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0014579395014721$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3536,27901,27902,45756</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8557115$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Masuzaki, Hiroaki</creatorcontrib><creatorcontrib>Hosoda, Kiminori</creatorcontrib><creatorcontrib>Ogawa, Yoshihiro</creatorcontrib><creatorcontrib>Shigemoto, Michika</creatorcontrib><creatorcontrib>Satoh, Noriko</creatorcontrib><creatorcontrib>Mori, Kiyoshi</creatorcontrib><creatorcontrib>Tamura, Naohisa</creatorcontrib><creatorcontrib>Nishi, Shigeo</creatorcontrib><creatorcontrib>Yoshimasa, Yasunao</creatorcontrib><creatorcontrib>Yamori, Yukio</creatorcontrib><creatorcontrib>Nakao, Kazuwa</creatorcontrib><title>Augmented expression of obese ( ob) gene during the process of obesity in genetically obese-hyperglycemic Wistar fatty ( falfa) rats</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>Expression of the
obese (
ob) gene is up-regulated in the adipose tissue in several obese rodent models. To study the regulation of the
ob gene expression during the development of obesity, we examined the
ob gene expression in genetically obese-hyperglycemic Wistar fatty (
falfa) rats at several stages of obesity. The
ob mRNA levels in the adipose tissue from Wistar fatty rats was unequivocally augmented and continued to rise in the process of obesity. Furthermore, the
ob gene expression in this obese model was much more rapidly enhanced in the mesenteric fat than in the subcutaneous fat. Moreover, the
ob gene expression was more greatly augmented in the mesenteric fat than the lipoprotein lipase gene expression. These results suggest the presence of obesity-linked and region-specific regulation of the
ob gene expression.</description><subject>Adipose Tissue - chemistry</subject><subject>Age Factors</subject><subject>Animals</subject><subject>Body Weight</subject><subject>Disease Models, Animal</subject><subject>Gene Expression</subject><subject>Hyperglycemia - complications</subject><subject>Hyperglycemia - genetics</subject><subject>Leptin</subject><subject>Lipoprotein Lipase - genetics</subject><subject>Male</subject><subject>obese ( ob) gene</subject><subject>Obese rodent models</subject><subject>Obesity - complications</subject><subject>Obesity - genetics</subject><subject>Obesity-linked regulation</subject><subject>Proteins - genetics</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>RNA, Messenger - analysis</subject><subject>Tissue Distribution</subject><subject>Wistar fatty ( falfa) rat</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNqNkU1v1DAQhi1EVZbCPwDJJ7R7CLUTO7YvSKXqAlKlXkAcLa8z3hrlY7EdIHd-OM5m6RF6Gs_MM689fhF6RclbSmh9SQhlBReqWiu-yWdRFvQJWlEpqqJitXyKVg_IM_Q8xm8k55Kqc3QuOReU8hX6fTXuO-gTNBh-HQLE6IceDw4PO4iA1zlu8B56wM0YfL_H6R7wIQw2k38xnybs-yOVvDVtOy3Txf10gLBvJwudt_irj8kE7EzK_DrH1pkNDibFF-gsZxFenuIF-rK9-Xz9sbi9-_Dp-uq2sEwpWpSclE5KR7iB2kpbEV66HbNC0orWvKRAlVUVk6YmQgFrds4xmjdtlGuAs-oCvVl08wLfR4hJdz5aaFvTwzBGLYQSrGT0vyAVhBPGZAbZAtowxBjA6UPwnQmTpkTPLunZAj1boBXXR5f0rP_6pD_uOmgehk625P526f_0LUyP0tTbm_fl3Jjrih-r80XvFiHI3_rDQ9DReugtND6ATboZ_L9f-gdWW7Rg</recordid><startdate>19960115</startdate><enddate>19960115</enddate><creator>Masuzaki, Hiroaki</creator><creator>Hosoda, Kiminori</creator><creator>Ogawa, Yoshihiro</creator><creator>Shigemoto, Michika</creator><creator>Satoh, Noriko</creator><creator>Mori, Kiyoshi</creator><creator>Tamura, Naohisa</creator><creator>Nishi, Shigeo</creator><creator>Yoshimasa, Yasunao</creator><creator>Yamori, Yukio</creator><creator>Nakao, Kazuwa</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>19960115</creationdate><title>Augmented expression of obese ( ob) gene during the process of obesity in genetically obese-hyperglycemic Wistar fatty ( falfa) rats</title><author>Masuzaki, Hiroaki ; Hosoda, Kiminori ; Ogawa, Yoshihiro ; Shigemoto, Michika ; Satoh, Noriko ; Mori, Kiyoshi ; Tamura, Naohisa ; Nishi, Shigeo ; Yoshimasa, Yasunao ; Yamori, Yukio ; Nakao, Kazuwa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4991-2502f88f05ae6c8c3052fb4c781316521e19c9348a6079e4dbff41557d9fde543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adipose Tissue - chemistry</topic><topic>Age Factors</topic><topic>Animals</topic><topic>Body Weight</topic><topic>Disease Models, Animal</topic><topic>Gene Expression</topic><topic>Hyperglycemia - complications</topic><topic>Hyperglycemia - genetics</topic><topic>Leptin</topic><topic>Lipoprotein Lipase - genetics</topic><topic>Male</topic><topic>obese ( ob) gene</topic><topic>Obese rodent models</topic><topic>Obesity - complications</topic><topic>Obesity - genetics</topic><topic>Obesity-linked regulation</topic><topic>Proteins - genetics</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>RNA, Messenger - analysis</topic><topic>Tissue Distribution</topic><topic>Wistar fatty ( falfa) rat</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Masuzaki, Hiroaki</creatorcontrib><creatorcontrib>Hosoda, Kiminori</creatorcontrib><creatorcontrib>Ogawa, Yoshihiro</creatorcontrib><creatorcontrib>Shigemoto, Michika</creatorcontrib><creatorcontrib>Satoh, Noriko</creatorcontrib><creatorcontrib>Mori, Kiyoshi</creatorcontrib><creatorcontrib>Tamura, Naohisa</creatorcontrib><creatorcontrib>Nishi, Shigeo</creatorcontrib><creatorcontrib>Yoshimasa, Yasunao</creatorcontrib><creatorcontrib>Yamori, Yukio</creatorcontrib><creatorcontrib>Nakao, Kazuwa</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Masuzaki, Hiroaki</au><au>Hosoda, Kiminori</au><au>Ogawa, Yoshihiro</au><au>Shigemoto, Michika</au><au>Satoh, Noriko</au><au>Mori, Kiyoshi</au><au>Tamura, Naohisa</au><au>Nishi, Shigeo</au><au>Yoshimasa, Yasunao</au><au>Yamori, Yukio</au><au>Nakao, Kazuwa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Augmented expression of obese ( ob) gene during the process of obesity in genetically obese-hyperglycemic Wistar fatty ( falfa) rats</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1996-01-15</date><risdate>1996</risdate><volume>378</volume><issue>3</issue><spage>267</spage><epage>271</epage><pages>267-271</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>Expression of the
obese (
ob) gene is up-regulated in the adipose tissue in several obese rodent models. To study the regulation of the
ob gene expression during the development of obesity, we examined the
ob gene expression in genetically obese-hyperglycemic Wistar fatty (
falfa) rats at several stages of obesity. The
ob mRNA levels in the adipose tissue from Wistar fatty rats was unequivocally augmented and continued to rise in the process of obesity. Furthermore, the
ob gene expression in this obese model was much more rapidly enhanced in the mesenteric fat than in the subcutaneous fat. Moreover, the
ob gene expression was more greatly augmented in the mesenteric fat than the lipoprotein lipase gene expression. These results suggest the presence of obesity-linked and region-specific regulation of the
ob gene expression.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>8557115</pmid><doi>10.1016/0014-5793(95)01472-1</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 1996-01, Vol.378 (3), p.267-271 |
| issn | 0014-5793 1873-3468 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77974241 |
| source | ScienceDirect |
| subjects | Adipose Tissue - chemistry Age Factors Animals Body Weight Disease Models, Animal Gene Expression Hyperglycemia - complications Hyperglycemia - genetics Leptin Lipoprotein Lipase - genetics Male obese ( ob) gene Obese rodent models Obesity - complications Obesity - genetics Obesity-linked regulation Proteins - genetics Rats Rats, Wistar RNA, Messenger - analysis Tissue Distribution Wistar fatty ( falfa) rat |
| title | Augmented expression of obese ( ob) gene during the process of obesity in genetically obese-hyperglycemic Wistar fatty ( falfa) rats |
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