Regulation of APP Expression, Biogenesis and Metabolism by Extracellular Matrix and Cytokines

We have identified and characterized the ligand binding properties of the Alzheimer's disease (AD) beta A4 amyloid protein precursor (APP), mapped the APP ligand binding sites and analyzed the regulation of APP expression, biogenesis and metabolism by components of the extracellular matrix (ECM...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1996-01, Vol.777 (1), p.74-76
Main Authors: BEYREUTHER, K., MULTHAUP, G., MÖNNING, U., SANDBRINK, R., BEHER, D., HESSE, L., SMALL, D. H., MASTERS, C.L.
Format: Article
Language:English
Subjects:
Amyloid beta-Protein Precursor - metabolism
Cytokines - physiology
Extracellular Matrix - physiology
Humans
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Summary:We have identified and characterized the ligand binding properties of the Alzheimer's disease (AD) beta A4 amyloid protein precursor (APP), mapped the APP ligand binding sites and analyzed the regulation of APP expression, biogenesis and metabolism by components of the extracellular matrix (ECM) and cytokines.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1996.tb34403.x