Glucocorticosteroid inhibition of cytokine production: Relevance to antiallergic actions

We believe that there are the following four classes of glucocorticoid-sensitive cytokines that are involved in cell recruitment: (1) those that activate endothelium nonspecifically; (2) those that activate endothelium specifically; (3) those that activate, prime, and prolong the survival of eosinop...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 1996, Vol.97 (1), p.143-152
Main Authors: Schwiebert, Lisa A., Beck, Lisa A., Stellato, Cristiana, Bickel, Carol A., Bochner, Bruce S., Schleimer, Robert P.
Format: Article
Language:English
Subjects:
Anti-Allergic Agents - pharmacology
Cytokines - antagonists & inhibitors
Glucocorticoids - pharmacology
Humans
Hypersensitivity - drug therapy
Hypersensitivity - immunology
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Summary:We believe that there are the following four classes of glucocorticoid-sensitive cytokines that are involved in cell recruitment: (1) those that activate endothelium nonspecifically; (2) those that activate endothelium specifically; (3) those that activate, prime, and prolong the survival of eosinophils; and (4) those that stimulate movement of cells up into the epithelium. Glucocorticoids inhibit the generation of these cytokines and thereby prevent several different aspects of inflamation, including the activation and recruitment of inflammatory cells (eosinophils, basophils, and lymphocytes) and the release of inflammatory mediators. We believe such pleiotropic actions account for the efficacy and widespread use of glucocorticoids in the treatment of asthma.
ISSN:0091-6749
1097-6825
DOI:10.1016/S0091-6749(96)80214-4