Zinc supplementation increases growth and circulating insulin-like growth factor I (IGF-I) in growth-retarded Vietnamese children

To determine whether zinc deficiency might be involved in the failure to thrive observed in undernourished Vietnamese children, we assessed growth, incidence of infections, and circulating insulin-like growth factor I (IGF-I) concentrations in a double-blind study of zinc supplementation. Growth-ret...

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Bibliographic Details
Published in:The American journal of clinical nutrition 1996-04, Vol.63 (4), p.514-519
Main Authors: Ninh, NX, Thissen, JP, Collette, L, Gerard, G, Khoi, HH, Ketelslegers, JM
Format: Article
Language:English
Subjects:
Anthropometry
Biological and medical sciences
Child, Preschool
Children & youth
Communicable Diseases - complications
Communicable Diseases - epidemiology
Diet
Double-Blind Method
Female
Food, Fortified
Growth - drug effects
Growth - physiology
Growth Disorders - complications
Growth Disorders - epidemiology
Growth Disorders - physiopathology
Humans
Incidence
Infant
Insulin-Like Growth Factor I - analysis
Logistic Models
Male
Malnutrition
Medical sciences
Metabolic diseases
Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)
Physical growth
Risk Factors
Vietnam - epidemiology
Zinc
Zinc - administration & dosage
Zinc - deficiency
Zinc - pharmacology
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Summary:To determine whether zinc deficiency might be involved in the failure to thrive observed in undernourished Vietnamese children, we assessed growth, incidence of infections, and circulating insulin-like growth factor I (IGF-I) concentrations in a double-blind study of zinc supplementation. Growth-retarded children (n=146) aged 4–36 mo were paired according to age, sex, commune, Z scores for weight (WAZ) and for height (HAZ), and number of siblings, and were randomly assigned to receive either 153 micromol (10 mg) Zn/d or a placebo for 5 mo. Weight, height, and episodes of infection were recorded each month and plasma IGF-I was measured 1 and 5 mo after the start of zinc supplementation. Multiple-linear-regression analysis for paired data showed that zinc supplementation increased weight (+0.5 +/- 0.1 kg; P
ISSN:0002-9165
1938-3207
DOI:10.1093/ajcn/63.4.514