BE-29602, a New Member of the Papulacandin Family

In the course of our screening program for new antifungal antibiotics, a fungal strain F29602 was found to produce a new antifungal antibiotic, BE-29602, which belonged to the family of Papulacandin. This strain, F29602, was isolated from a soil sample collected in Saitama Prefecture, Japan. Based o...

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Bibliographic Details
Published in:Journal of antibiotics 1996/01/25, Vol.49(1), pp.103-106
Main Authors: OKADA, HIROMASA, NAGASHIMA, MASAO, SUZUKI, HAJIME, NAKAJIMA, SHIGERU, KOJIRI, KATSUHISA, SUDA, HIROYUKI
Format: Article
Language:English
Subjects:
Aminoglycosides
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - chemistry
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
Biological and medical sciences
Echinocandins
Fermentation
Fusarium
Fusarium - metabolism
Glycosides - chemistry
Glycosides - isolation & purification
Glycosides - pharmacology
Medical sciences
Mice
Pharmacology. Drug treatments
Tumor Cells, Cultured
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Summary:In the course of our screening program for new antifungal antibiotics, a fungal strain F29602 was found to produce a new antifungal antibiotic, BE-29602, which belonged to the family of Papulacandin. This strain, F29602, was isolated from a soil sample collected in Saitama Prefecture, Japan. Based on the cultural and morphological characteristics, strain F29602 was identified as belonging to the genus Fusarium. BE-29062 was soluble in methanol and dimethyl sulfoxide (DMSO), but insoluble in chloroform and water. Its molecular formula was established as C sub(45)H sub(62)O sub(16) from the HRFAB-MS and NMR spectral analyses. Its IR spectrum showed the presence of alpha , beta -unsaturated ester at 1710 cm super(-1).
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.49.103