Lack of autoantibody expression in children born to mothers with silicone breast implants

We determined systematically the prevalence of autoantibodies in children born to mothers with silicone breast implants and the relationships with clinical symptoms and methods of exposure. Autoantibody expression was determined in 80 children born to mothers with silicone implants and in 42 control...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1996-02, Vol.97 (2), p.243-245
Main Authors: LEVINE, J. J, LIN, H.-C, ROWLEY, M, COOK, A, TEUBER, S. S, ILOWITE, N. T
Format: Article
Language:English
Subjects:
Adolescent
Adult
Allergic diseases
Antibodies, Antinuclear - biosynthesis
Autoantibodies
Autoantibodies - biosynthesis
Babies
Biological and medical sciences
Breast Implants
Breast prosthesis
Child
Child, Preschool
Female
Humans
Immunity (Disease)
Immunopathology
Infant
Infant Nutritional Physiological Phenomena
Infants (Newborn)
Male
Medical sciences
Medical silicones
Mothers
Newborn infants
Other localizations
Pediatrics
Physiological aspects
Pregnancy
Silicones
Silicones in medicine
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Summary:We determined systematically the prevalence of autoantibodies in children born to mothers with silicone breast implants and the relationships with clinical symptoms and methods of exposure. Autoantibody expression was determined in 80 children born to mothers with silicone implants and in 42 controls. A clinical assessment score was assigned to each patient. Antinuclear antibodies as well as antibodies to mitochondrial, smooth muscle, striational, myocardial, parietal cell, reticulin tissues, or subcellular compartments were measured by indirect fluorescent assay. Antibodies to nRNP (U1-RNP/snRNP); Sm; SS-A; SS-B; Scl-70; thyroid microsome; immunoglobulin (Ig)G, IgM, and IgA antibodies to cardiolipin; and antibodies to native and denatured human types I and II collagen were measured by enzyme-linked immunosorbent assay. Serum complement components C3 and C4 and IgM rheumatoid factor were measured by nephelometry. Autoantibody prevalence was not significantly different between children born to mothers with silicone implants and controls. The presence of autoantibodies was not related to the children's clinical symptoms or to the method of exposure. Determination of autoantibody production is of limited clinical utility in the evaluation of children born to mothers with silicone breast implants.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.97.2.243