Traumatic Hypothermia Is Related to Hypotension, Not Resuscitation

Study objective: To determine whether posttraumatic hypothermia is associated with hemorrhage or with resuscitation. Methods: We used a sequential hemorrhage-resuscitation rat model. Rats were subjected to hemorrhage (30 mL/kg), then 1 hour of shock, followed by 2:1 crystalloid/blood resuscitation (...

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Bibliographic Details
Published in:Annals of emergency medicine 1996, Vol.27 (1), p.39-42
Main Authors: Bergstein, Jack M, Slakey, Douglas P, Wallace, James R, Gottlieb, Mark
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animals
Biological and medical sciences
Blood Pressure
Body Temperature
Disease Models, Animal
Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care
Hypothermia - etiology
Intensive care medicine
Linear Models
Male
Medical sciences
Rats
Rats, Sprague-Dawley
Resuscitation - adverse effects
Shock, Hemorrhagic - complications
Shock, Hemorrhagic - mortality
Shock, Hemorrhagic - therapy
Wounds and Injuries - complications
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Summary:Study objective: To determine whether posttraumatic hypothermia is associated with hemorrhage or with resuscitation. Methods: We used a sequential hemorrhage-resuscitation rat model. Rats were subjected to hemorrhage (30 mL/kg), then 1 hour of shock, followed by 2:1 crystalloid/blood resuscitation (60 mL/kg) at ambient temperature. A control group underwent neither hemorrhage nor resuscitation. Results: We recorded core temperature and blood pressure every 10 minutes. Temperature drop averaged 3.4°C and was fastest during hypotensive shock. Rate of temperature change correlated with blood pressure (β=.0102, P
ISSN:0196-0644
1097-6760
DOI:10.1016/S0196-0644(96)70294-9