Progesterone Rapidly Decreases Brain Edema: Treatment Delayed up to 24 Hours Is Still Effective

Cerebral edema is a serious side effect of traumatic brain injury. We have previously established that progesterone injections, initiated within 1 h after cortical contusion injury, reduced edema when assessed 3 days later. To determine how rapidly progesterone can reduce edema, male and female rats...

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Bibliographic Details
Published in:Experimental neurology 1996-04, Vol.138 (2), p.246-251
Main Authors: Roof, Robin L., Duvdevani, Revital, Heyburn, John W., Stein, Donald G.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain Concussion - complications
Brain Edema - drug therapy
Brain Edema - etiology
Female
Male
Medical sciences
Neuropharmacology
Neuroprotective agent
Pharmacology. Drug treatments
Progesterone - administration & dosage
Progesterone - therapeutic use
Rats
Rats, Sprague-Dawley
Time Factors
Citations: Items that cite this one
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Summary:Cerebral edema is a serious side effect of traumatic brain injury. We have previously established that progesterone injections, initiated within 1 h after cortical contusion injury, reduced edema when assessed 3 days later. To determine how rapidly progesterone can reduce edema, male and female rats were given the hormone 1 h after damage to the medial frontal cortex, and edema levels were assessed between 2 h and 7 days postinjury. Progesterone decreased edema within 6 h of the injury and continued to be effective for the duration of treatment. In addition, we assessed whether progesterone injections are effective when delays are imposed between injury and initiation of treatment. Male and female rats received progesterone after postinjury delays of 6, 24, or 48 h. Progesterone was effective in reducing edema when treatment was delayed until 24 h after injury.
ISSN:0014-4886
1090-2430
DOI:10.1006/exnr.1996.0063