Isolation and characterization of the mouse ( Mus musculus) somatostatin receptor type-4-encoding gene ( mSSTR4)

We have isolated and sequenced the mouse somatostatin receptor subtype-4-encoding gene ( mSSTR4). The mSSTR4 gene encodes 384 amino acids (aa). The deduced mouse SSTR4 has 95 and 89% aa identity with the deduced rat and human SSTR4, respectively, while it has lower aa identity with the other mouse s...

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Bibliographic Details
Published in:Gene 1996-02, Vol.168 (2), p.233-235
Main Authors: Schwabe, Wolfgang, Brennan, Miles B., Hochgeschwender, Ute
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Brain - metabolism
DNA Primers
expression
Gene cloning
Gene Expression
Humans
Membrane Proteins
Mice - genetics
Molecular Sequence Data
nucleotide sequence
oligodeoxynucleotide hybridization
Organ Specificity
Polymerase Chain Reaction
Rats
Receptors, Somatostatin - biosynthesis
Receptors, Somatostatin - chemistry
Receptors, Somatostatin - genetics
RT-PCR
Sequence Homology, Amino Acid
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Description
Summary:We have isolated and sequenced the mouse somatostatin receptor subtype-4-encoding gene ( mSSTR4). The mSSTR4 gene encodes 384 amino acids (aa). The deduced mouse SSTR4 has 95 and 89% aa identity with the deduced rat and human SSTR4, respectively, while it has lower aa identity with the other mouse subtypes (mSSTR1, 60%; mSSTR2, 47%; mSSTR3, 42%). Using an RT-PCR technique, we show that the mSSTR4 gene is expressed in brain, but not in liver, heart, spleen or kidney of the adult mouse.
ISSN:0378-1119
1879-0038
DOI:10.1016/0378-1119(95)00748-2