Staphylococcus aureus Small Colony Variants Are Induced by the Endothelial Cell Intracellular Milieu

Recent studies have reported that Staphylococcus aureus small colony variants (SCVs) can cause highly persistent infections in humans and in cultured endothelial cells. To understand the process by which SCVs of S. aureus appear in subjects who have not received antibiotic treatment, bovine endothel...

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Bibliographic Details
Published in:The Journal of infectious diseases 1996-03, Vol.173 (3), p.739-742
Main Authors: Vesga, Omar, Groeschel, Michael C., Otten, Marijke F., Brar, Dorothy W., Vann, James M., Proctor, Richard A.
Format: Article
Language:English
Subjects:
Animals
Antibiotics
Bacteria
Bacterial diseases
Biological and medical sciences
Cattle
Cell Line
Concise Communications
Cultured cells
Endothelial cells
Endothelium, Vascular - cytology
Endothelium, Vascular - microbiology
Endothelium, Vascular - physiopathology
Gentamicins - pharmacology
Human bacterial diseases
Humans
Infections
Infectious diseases
Inoculum
Intracellular Fluid - microbiology
Intracellular Fluid - physiology
Medical sciences
Phenotypes
Staphylococcal Infections - etiology
Staphylococcal Infections - microbiology
Staphylococcal Infections - physiopathology
Staphylococcal infections, streptococcal infections, pneumococcal infections
Staphylococcus
Staphylococcus aureus
Staphylococcus aureus - drug effects
Staphylococcus aureus - growth & development
Staphylococcus aureus - pathogenicity
Ungulates
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Summary:Recent studies have reported that Staphylococcus aureus small colony variants (SCVs) can cause highly persistent infections in humans and in cultured endothelial cells. To understand the process by which SCVs of S. aureus appear in subjects who have not received antibiotic treatment, bovine endothelial cells were coincubated with a wild S. aureus strain for 72 h in the presence of lysostaphin. Intracellular bacteria were harvested and screened for stable SCVs. Intracellular bacteria developed the SCV phenotype at a greater rate than control bacteria not exposed to endothelial cells: The intracellular induction rate was ∼ 10−3 versus a spontaneous rate of
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/173.3.739