A novel chimera gene between EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein, in extraosseous Ewing's sarcoma

Ewing's sarcoma/PNET, a tumor of the bone and soft tissue, is one of the most common causes of tumor death among youths. This tumor does not have specific phenotypes, but does have characteristic chromosomal translocations. Furthermore, the expression of EWS/FLI-1 or EWS/ERG chimeric genes was...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 1996-02, Vol.219 (2), p.608-612
Main Authors: Urano, F, Umezawa, A, Hong, W, Kikuchi, H, Hata, J
Format: Article
Language:English
Subjects:
Adenovirus E1A Proteins - biosynthesis
Adenovirus E1A Proteins - genetics
Adolescent
Base Sequence
Cloning, Molecular
DNA Primers
DNA, Neoplasm
Heterogeneous-Nuclear Ribonucleoproteins
Humans
Male
Molecular Sequence Data
Neoplasm Proteins - biosynthesis
Neoplasm Proteins - genetics
Polymerase Chain Reaction
Proto-Oncogene Proteins - biosynthesis
Proto-Oncogene Proteins - genetics
Ribonucleoproteins - biosynthesis
Ribonucleoproteins - genetics
RNA-Binding Protein EWS
Sarcoma, Ewing - genetics
Sarcoma, Ewing - metabolism
Sarcoma, Ewing - pathology
Sarcoma, Ewing - ultrastructure
Soft Tissue Neoplasms - genetics
Soft Tissue Neoplasms - metabolism
Soft Tissue Neoplasms - pathology
Soft Tissue Neoplasms - ultrastructure
Translocation, Genetic
Tumor Cells, Cultured
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Summary:Ewing's sarcoma/PNET, a tumor of the bone and soft tissue, is one of the most common causes of tumor death among youths. This tumor does not have specific phenotypes, but does have characteristic chromosomal translocations. Furthermore, the expression of EWS/FLI-1 or EWS/ERG chimeric genes was found to be generated through a t(11;22)(q24;q12) or a t(21;22)(q22;q12) translocation. In this study, we identified a new chimera gene between the transactivation domain of EWS and E1A-F, encoding the adenovirus E1A enhancer-binding protein. Since E1A-F is known to activate matrix metalloproteinase genes, the chimera gene may possibly be involved in tumor progression and could be a novel tumor marker for Ewing's sarcoma/PNET.
ISSN:0006-291X
DOI:10.1006/bbrc.1996.0281