t(7;11) and trilineage myelodysplasia in acute myelomonocytic leukemia

• Published in: Cancer genetics and cytogenetics 1996, Vol.86 (1), p.72-75
• Main Authors: Inaba, Tohru, Shimazaki, Chihiro, Yoneyama, Satoshi, Hirai, Hideyo, Kikuta, Takehisa, Sumikuma, Toshiya, Sudo, Yoshikazu, Yamagata, Noboru, Ashihara, Eishi, Goto, Hideo, Fujita, Naohisa, Nakagawa, Masao
• Format: Article
• Language: English
• Subjects: Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Bone Marrow - pathology; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 7; Fatal Outcome; Hematologic and hematopoietic diseases; Humans; Japan; Karyotyping; Leukemia, Myelomonocytic, Acute - drug therapy; Leukemia, Myelomonocytic, Acute - genetics; Leukemia, Myelomonocytic, Acute - pathology; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Male; Medical sciences; Middle Aged; Myelodysplastic Syndromes - drug therapy; Myelodysplastic Syndromes - genetics; Myelodysplastic Syndromes - pathology; Translocation, Genetic
• ISSN: 0165-4608; 1873-4456
• DOI: 10.1016/0165-4608(95)00160-3

A 48-year-old Japanese man was admitted to our hospital because of general fatigue, nasal bleeding, and petechiae on his extremities. He was diagnosed with acute myelomonocytic leukemia with trilineage myelodysplasia (T-MDS). Chromosomal analysis of bone marrow cells revealed t(7;11)(p15;p15), which has been rarely reported but known to be characteristic of Japanese patients. Although t(7;11)(p15;p15) has been reported mainly in acute myelogenous leukemia (AML), it can be occasionally found in so-called stem cell diseases such as chronic myelogenous leukemia or chronic myeloproliferative disorders. Therefore, t(7;11)(p15;p15) might affect trilineage progenitors or stem cells as well as myeloid lineage cells, subsequently resulting in AML with T-MDS, as in our case reported here.