Loading…
Dose related response to clozapine in a state psychiatric hospital population : a naturalistic study
After noting a striking difference in the dosing practices of two treating psychiatrists, each responsible for the operation of a clozapine unit in a state psychiatric hospital, the authors conducted a retrospective chart review to assess the clinical efficacy of low dose x = 294 mg. per day) versus...
Saved in:
| Published in: | Psychiatric quarterly 1996, Vol.67 (1), p.65-74 |
|---|---|
| Main Authors: | , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c311t-41157ae45fa82c3026cfc90c3d7f01f7db0f37d1e000d3b9ba9a7db628a6915c3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c311t-41157ae45fa82c3026cfc90c3d7f01f7db0f37d1e000d3b9ba9a7db628a6915c3 |
| container_end_page | 74 |
| container_issue | 1 |
| container_start_page | 65 |
| container_title | Psychiatric quarterly |
| container_volume | 67 |
| creator | GORDON, B. J MILKE, D. J |
| description | After noting a striking difference in the dosing practices of two treating psychiatrists, each responsible for the operation of a clozapine unit in a state psychiatric hospital, the authors conducted a retrospective chart review to assess the clinical efficacy of low dose x = 294 mg. per day) versus high dose (x = 525 mg. per day) clozapine treatment for a cohort of 31 inpatients. Levels of psychopathology, behavior, and social functioning were assessed six months pre and during clozapine treatment for 16 patients who received low dose clozapine treatment and 15 patients who received high dose clozapine treatment. Patients on both units demonstrated significant reductions in their levels of psychopathology, improved social functioning and improvement in their behavior following six months clozapine treatment. This naturalistic study suggests that the use of low dose clozapine provides effective treatment for chronic, severely treatment resistant inpatients with schizophrenia or schizo-affective illness, at the same time reducing the potential for significant side effects. |
| doi_str_mv | 10.1007/BF02244276 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78011046</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78011046</sourcerecordid><originalsourceid>FETCH-LOGICAL-c311t-41157ae45fa82c3026cfc90c3d7f01f7db0f37d1e000d3b9ba9a7db628a6915c3</originalsourceid><addsrcrecordid>eNpFkM1LxDAQxYMo6_px8S7kIB6E6iTpJltvuroqCF70XGbTFCPdpmbSw_rXG3HR04P3fvMYHmMnAi4FgLm6XYKUZSmN3mFTMTOq0AaqXTYFUKqQRsI-OyD6ABBCKzlhk7mWCkqYsuYukOPRdZhck5WG0GcjBW678IWD7x33PUdOKRN8oI1995iit_w90OATdnwIw5jvfej5dSZ7TGPEzlPKEKWx2RyxvRY7csdbPWRvy_vXxWPx_PLwtLh5LqwSIhWlyL-jK2ctzqVVILVtbQVWNaYF0ZpmBa0yjXAA0KhVtcIKs6nlHHUlZlYdsvPf3iGGz9FRqteerOs67F0YqTbzPACUOoMXv6CNgSi6th6iX2Pc1ALqn0nr_0kzfLptHVdr1_yh2w1zfrbNkSx2bcTeevrDZKXBlFJ9A1vPfmY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78011046</pqid></control><display><type>article</type><title>Dose related response to clozapine in a state psychiatric hospital population : a naturalistic study</title><source>Springer Nature - Connect here FIRST to enable access</source><creator>GORDON, B. J ; MILKE, D. J</creator><creatorcontrib>GORDON, B. J ; MILKE, D. J</creatorcontrib><description>After noting a striking difference in the dosing practices of two treating psychiatrists, each responsible for the operation of a clozapine unit in a state psychiatric hospital, the authors conducted a retrospective chart review to assess the clinical efficacy of low dose x = 294 mg. per day) versus high dose (x = 525 mg. per day) clozapine treatment for a cohort of 31 inpatients. Levels of psychopathology, behavior, and social functioning were assessed six months pre and during clozapine treatment for 16 patients who received low dose clozapine treatment and 15 patients who received high dose clozapine treatment. Patients on both units demonstrated significant reductions in their levels of psychopathology, improved social functioning and improvement in their behavior following six months clozapine treatment. This naturalistic study suggests that the use of low dose clozapine provides effective treatment for chronic, severely treatment resistant inpatients with schizophrenia or schizo-affective illness, at the same time reducing the potential for significant side effects.</description><identifier>ISSN: 0033-2720</identifier><identifier>EISSN: 1573-6709</identifier><identifier>DOI: 10.1007/BF02244276</identifier><identifier>PMID: 8623040</identifier><identifier>CODEN: PSQUAP</identifier><language>eng</language><publisher>New York, NY: Springer</publisher><subject>Adult ; Antipsychotic Agents - administration & dosage ; Antipsychotic Agents - therapeutic use ; Biological and medical sciences ; Clozapine - administration & dosage ; Clozapine - therapeutic use ; Cohort Studies ; Dose-Response Relationship, Drug ; Female ; Hospitalization ; Hospitals, Psychiatric ; Humans ; Male ; Medical sciences ; Neuropharmacology ; Pharmacology. Drug treatments ; Psychiatric Status Rating Scales ; Psycholeptics: tranquillizer, neuroleptic ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Psychotic Disorders - diagnosis ; Psychotic Disorders - drug therapy ; Retrospective Studies ; Schizophrenia - diagnosis ; Schizophrenia - drug therapy ; Treatment Outcome</subject><ispartof>Psychiatric quarterly, 1996, Vol.67 (1), p.65-74</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c311t-41157ae45fa82c3026cfc90c3d7f01f7db0f37d1e000d3b9ba9a7db628a6915c3</citedby><cites>FETCH-LOGICAL-c311t-41157ae45fa82c3026cfc90c3d7f01f7db0f37d1e000d3b9ba9a7db628a6915c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2960742$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8623040$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GORDON, B. J</creatorcontrib><creatorcontrib>MILKE, D. J</creatorcontrib><title>Dose related response to clozapine in a state psychiatric hospital population : a naturalistic study</title><title>Psychiatric quarterly</title><addtitle>Psychiatr Q</addtitle><description>After noting a striking difference in the dosing practices of two treating psychiatrists, each responsible for the operation of a clozapine unit in a state psychiatric hospital, the authors conducted a retrospective chart review to assess the clinical efficacy of low dose x = 294 mg. per day) versus high dose (x = 525 mg. per day) clozapine treatment for a cohort of 31 inpatients. Levels of psychopathology, behavior, and social functioning were assessed six months pre and during clozapine treatment for 16 patients who received low dose clozapine treatment and 15 patients who received high dose clozapine treatment. Patients on both units demonstrated significant reductions in their levels of psychopathology, improved social functioning and improvement in their behavior following six months clozapine treatment. This naturalistic study suggests that the use of low dose clozapine provides effective treatment for chronic, severely treatment resistant inpatients with schizophrenia or schizo-affective illness, at the same time reducing the potential for significant side effects.</description><subject>Adult</subject><subject>Antipsychotic Agents - administration & dosage</subject><subject>Antipsychotic Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Clozapine - administration & dosage</subject><subject>Clozapine - therapeutic use</subject><subject>Cohort Studies</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Hospitalization</subject><subject>Hospitals, Psychiatric</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psycholeptics: tranquillizer, neuroleptic</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Psychotic Disorders - diagnosis</subject><subject>Psychotic Disorders - drug therapy</subject><subject>Retrospective Studies</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenia - drug therapy</subject><subject>Treatment Outcome</subject><issn>0033-2720</issn><issn>1573-6709</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNpFkM1LxDAQxYMo6_px8S7kIB6E6iTpJltvuroqCF70XGbTFCPdpmbSw_rXG3HR04P3fvMYHmMnAi4FgLm6XYKUZSmN3mFTMTOq0AaqXTYFUKqQRsI-OyD6ABBCKzlhk7mWCkqYsuYukOPRdZhck5WG0GcjBW678IWD7x33PUdOKRN8oI1995iit_w90OATdnwIw5jvfej5dSZ7TGPEzlPKEKWx2RyxvRY7csdbPWRvy_vXxWPx_PLwtLh5LqwSIhWlyL-jK2ctzqVVILVtbQVWNaYF0ZpmBa0yjXAA0KhVtcIKs6nlHHUlZlYdsvPf3iGGz9FRqteerOs67F0YqTbzPACUOoMXv6CNgSi6th6iX2Pc1ALqn0nr_0kzfLptHVdr1_yh2w1zfrbNkSx2bcTeevrDZKXBlFJ9A1vPfmY</recordid><startdate>1996</startdate><enddate>1996</enddate><creator>GORDON, B. J</creator><creator>MILKE, D. J</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1996</creationdate><title>Dose related response to clozapine in a state psychiatric hospital population : a naturalistic study</title><author>GORDON, B. J ; MILKE, D. J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-41157ae45fa82c3026cfc90c3d7f01f7db0f37d1e000d3b9ba9a7db628a6915c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Antipsychotic Agents - administration & dosage</topic><topic>Antipsychotic Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Clozapine - administration & dosage</topic><topic>Clozapine - therapeutic use</topic><topic>Cohort Studies</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Hospitalization</topic><topic>Hospitals, Psychiatric</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psycholeptics: tranquillizer, neuroleptic</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Psychotic Disorders - diagnosis</topic><topic>Psychotic Disorders - drug therapy</topic><topic>Retrospective Studies</topic><topic>Schizophrenia - diagnosis</topic><topic>Schizophrenia - drug therapy</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GORDON, B. J</creatorcontrib><creatorcontrib>MILKE, D. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatric quarterly</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GORDON, B. J</au><au>MILKE, D. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dose related response to clozapine in a state psychiatric hospital population : a naturalistic study</atitle><jtitle>Psychiatric quarterly</jtitle><addtitle>Psychiatr Q</addtitle><date>1996</date><risdate>1996</risdate><volume>67</volume><issue>1</issue><spage>65</spage><epage>74</epage><pages>65-74</pages><issn>0033-2720</issn><eissn>1573-6709</eissn><coden>PSQUAP</coden><abstract>After noting a striking difference in the dosing practices of two treating psychiatrists, each responsible for the operation of a clozapine unit in a state psychiatric hospital, the authors conducted a retrospective chart review to assess the clinical efficacy of low dose x = 294 mg. per day) versus high dose (x = 525 mg. per day) clozapine treatment for a cohort of 31 inpatients. Levels of psychopathology, behavior, and social functioning were assessed six months pre and during clozapine treatment for 16 patients who received low dose clozapine treatment and 15 patients who received high dose clozapine treatment. Patients on both units demonstrated significant reductions in their levels of psychopathology, improved social functioning and improvement in their behavior following six months clozapine treatment. This naturalistic study suggests that the use of low dose clozapine provides effective treatment for chronic, severely treatment resistant inpatients with schizophrenia or schizo-affective illness, at the same time reducing the potential for significant side effects.</abstract><cop>New York, NY</cop><pub>Springer</pub><pmid>8623040</pmid><doi>10.1007/BF02244276</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0033-2720 |
| ispartof | Psychiatric quarterly, 1996, Vol.67 (1), p.65-74 |
| issn | 0033-2720 1573-6709 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78011046 |
| source | Springer Nature - Connect here FIRST to enable access |
| subjects | Adult Antipsychotic Agents - administration & dosage Antipsychotic Agents - therapeutic use Biological and medical sciences Clozapine - administration & dosage Clozapine - therapeutic use Cohort Studies Dose-Response Relationship, Drug Female Hospitalization Hospitals, Psychiatric Humans Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Psychiatric Status Rating Scales Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Psychotic Disorders - diagnosis Psychotic Disorders - drug therapy Retrospective Studies Schizophrenia - diagnosis Schizophrenia - drug therapy Treatment Outcome |
| title | Dose related response to clozapine in a state psychiatric hospital population : a naturalistic study |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T08%3A37%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dose%20related%20response%20to%20clozapine%20in%20a%20state%20psychiatric%20hospital%20population%20:%20a%20naturalistic%20study&rft.jtitle=Psychiatric%20quarterly&rft.au=GORDON,%20B.%20J&rft.date=1996&rft.volume=67&rft.issue=1&rft.spage=65&rft.epage=74&rft.pages=65-74&rft.issn=0033-2720&rft.eissn=1573-6709&rft.coden=PSQUAP&rft_id=info:doi/10.1007/BF02244276&rft_dat=%3Cproquest_cross%3E78011046%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c311t-41157ae45fa82c3026cfc90c3d7f01f7db0f37d1e000d3b9ba9a7db628a6915c3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=78011046&rft_id=info:pmid/8623040&rfr_iscdi=true |