Long-term follow-up of patients with early atherosclerosis

Purpose: Patients with premature peripheral vascular disease may respond differently than their older counterparts. To determine the impact of early onset of atherosclerosis on outcome, we decided to compare a group of these patients with a group of patients with typical onset of atherosclerosis wit...

Full description

Saved in:
Bibliographic Details
Published in:Journal of vascular surgery 1996-04, Vol.23 (4), p.576-581
Main Authors: Harris, Linda M., Peer, Richard, Richard Curl, G., Pillai, Lashmikumar, Upson, James, Ricotta, John J.
Format: Article
Language:English
Subjects:
Age of Onset
Aged
Aging
Amputation
Aortic Diseases - complications
Aortic Diseases - pathology
Aortic Diseases - surgery
Arteriosclerosis - complications
Arteriosclerosis - pathology
Arteriosclerosis - surgery
Cohort Studies
Follow-Up Studies
Humans
Iliac Artery - pathology
Inguinal Canal - blood supply
Intracranial Arteriosclerosis - complications
Intracranial Arteriosclerosis - pathology
Intracranial Arteriosclerosis - surgery
Life Tables
Longitudinal Studies
Middle Aged
Prognosis
Reoperation
Reperfusion
Retrospective Studies
Risk Factors
Survival Rate
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose: Patients with premature peripheral vascular disease may respond differently than their older counterparts. To determine the impact of early onset of atherosclerosis on outcome, we decided to compare a group of these patients with a group of patients with typical onset of atherosclerosis with regard to early complications, indications for intervention, site of disease at initial presentation (aortoiliac, infrainguinal, or cerebrovascular), and long-term outcomes (secondary revascularization, amputation, and death). Method: All patients younger than 50 years old requiring operative intervention between 1987 and 1992 were retrospectively compared with a group of patients greater than 60 years old, randomly selected from patients who underwent operation during the same time period. Patients were evaluated and compared for indications, risk factors, and early and late outcomes. Results: Patients with early onset atherosclerosis at the aortoiliac or infrainguinal level had a higher late amputation rate (17% versus 3.9%, p=0.02) and poorer overall outcome than their older cohorts. Patients with cerebrovascular disease in both cohorts had similarly good prognoses. Conclusion: Aortoiliac or infrainguinal disease diagnosed in patients less than 50 years of age portends a poorer outcome than does similar disease in an older patient population.
ISSN:0741-5214
1097-6809
DOI:10.1016/S0741-5214(96)80035-8