Coronary vasodilation induced by angiotensin-converting enzyme inhibition in vivo : Differential contribution of nitric oxide and bradykinin in conductance and resistance arteries

We studied in coronary conductance and resistance arteries the coronary vasodilator effects of the angiotensin-converting enzyme inhibitor ramiprilat and the contribution of nitric oxide, bradykinin, and prostaglandins to this vasodilation. In seven anesthetized dogs, a Doppler guidewire was placed...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1996-05, Vol.93 (9), p.1734-1739
Main Authors: KRISHNANKUTTY SUDHIR, CHOU, T. M, HUTCHISON, S. J, KANU CHATTERJEE
Format: Article
Language:English
Subjects:
Angiotensin-Converting Enzyme Inhibitors - pharmacology
Animals
Arginine - analogs & derivatives
Arginine - pharmacology
Biological and medical sciences
Bradykinin - analogs & derivatives
Bradykinin - pharmacology
Cardiovascular system
Coronary Vessels - drug effects
Coronary Vessels - physiology
Dogs
Echocardiography, Doppler
Indomethacin - pharmacology
Medical sciences
NG-Nitroarginine Methyl Ester
Nitric Oxide Synthase - antagonists & inhibitors
Pharmacology. Drug treatments
Ramipril - analogs & derivatives
Ramipril - pharmacology
Vascular Resistance - drug effects
Vasodilation - drug effects
Vasodilator agents. Cerebral vasodilators
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Summary:We studied in coronary conductance and resistance arteries the coronary vasodilator effects of the angiotensin-converting enzyme inhibitor ramiprilat and the contribution of nitric oxide, bradykinin, and prostaglandins to this vasodilation. In seven anesthetized dogs, a Doppler guidewire was placed in the circumflex coronary artery to measure coronary flow velocity, and an ultrasound imaging catheter was introduced over the Doppler wire to measure coronary cross-sectional area. Drugs were infused directly into the left main coronary artery to minimize systemic effects. Ramiprilat increased both epicardial cross-sectional area and coronary blood flow velocity, resulting in an increase in absolute coronary blood flow. Pretreatment with N omega-nitro-L-arginine methyl ester (100 micromol/L intracoronary) to block nitric oxide synthase attenuated ramiprilat-induced increase in epicardial coronary cross-sectional area (P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.93.9.1734