A preliminary metabolic study of alpidem in rat and man

The metabolism of alpidem, a new anxiolytic agent in the chemical series of imidazopyridines, was investigated in rat and man. In both species the compound is extensively metabolised by three main routes of biotransformation: aromatic oxidation of the imidazopyridine ring; n-dealkylation; and/or ali...

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Bibliographic Details
Published in:European journal of drug metabolism and pharmacokinetics 1987-10, Vol.12 (4), p.295-298
Main Authors: PADOVANI, P, GUINEBAULT, P, VAJTA, S, DURAND, A, ALLEN, J, THENOT, J. P, MORSELLI, P. L
Format: Article
Language:English
Subjects:
Adult
Animals
Bile - analysis
Biological and medical sciences
Biotransformation - drug effects
Humans
Imidazoles - analysis
Imidazoles - metabolism
Imidazoles - urine
Male
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Pyridines - analysis
Pyridines - metabolism
Pyridines - urine
Rats
Rats, Inbred Strains
Species Specificity
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Summary:The metabolism of alpidem, a new anxiolytic agent in the chemical series of imidazopyridines, was investigated in rat and man. In both species the compound is extensively metabolised by three main routes of biotransformation: aromatic oxidation of the imidazopyridine ring; n-dealkylation; and/or aliphatic oxidation of the substituted amide side chains.
ISSN:0378-7966
2107-0180
DOI:10.1007/BF03189916