Sensitivity of Fungi to Nikkomycin Z

Nikkomycin Z inhibited colony radial extension (Kr) and hyphal density inGeotrichum candidum, Trichoderma koningii, Mucor plumbeus,andFusarium oxysporum,although the level of inhibition varied with the fungal species and was influenced by the concentration of nutrients in the culture medium. WhileG....

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Bibliographic Details
Published in:Fungal genetics and biology 1996-03, Vol.20 (1), p.4-11
Main Authors: Tariq, Vicki N., Devlin, Pauline L.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Aminoglycosides
Anti-Bacterial Agents - metabolism
Anti-Bacterial Agents - pharmacology
antibiotic resistance
Antifungal Agents - pharmacology
Antifungal antibiotics
antifungal properties
Biological Transport
Cell Wall - drug effects
Chitin - biosynthesis
Culture Media
damage
dipeptides
Dipeptides - metabolism
drug resistance
Drug Resistance, Microbial
Enzyme Inhibitors - pharmacology
Fusarium oxysporum f. sp. lycopersici
Genetic Variation
Geotrichum candidum
growth rate
hyphae
Hypocrea koningii
Microbial Sensitivity Tests
Molecular Sequence Data
Mucor
mucor plumbeus
nikkomycin Z
nikkomycins
oligopeptides
Oligopeptides - metabolism
peptide uptake
species differences
Species Specificity
tripeptides
uptake
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Summary:Nikkomycin Z inhibited colony radial extension (Kr) and hyphal density inGeotrichum candidum, Trichoderma koningii, Mucor plumbeus,andFusarium oxysporum,although the level of inhibition varied with the fungal species and was influenced by the concentration of nutrients in the culture medium. WhileG. candidumandM. plumbeuswere sensitive to the inhibitory effects of nikkomycin Z,T. koningiiandF. oxysporumwere relatively tolerant of concentrations of the antibiotic up to 100 μmol. Nikkomycin Z also caused significant decreases in rates of hyphal extension (Emax) and swelling and bursting of hyphal apices inG. candidumandM. plumbeus.The sensitivity ofG. candidumandM. plumbeusto the effects of the antibiotic was due in part to their ability to remove nikkomycin from a liquid culture medium; the nikkomycin-tolerant speciesT. koningiiandF. oxysporumwere unable to transport this nucleoside dipeptide antibiotic. Although bothG. candidumandF. oxysporumappeared capable of removing the di- and tripeptides, dialanine and trialanine, from a liquid medium, rate of dipeptide uptake was greater inF. oxysporum,while rate of tripeptide uptake was greater inG. candidum.However, overall rate of uptake of peptides was greater inG. candidumthan inF. oxysporum.
ISSN:1087-1845
1096-0937
DOI:10.1006/fgbi.1996.0003