Application of accelerator mass spectrometry (AMS) for high-sensitivity measurements of 14CO2 in long-term studies of fat metabolism

Long-term measurements of 14C in CO2 expired after ingestion of 14C-labelled triolein were performed using accelerator mass spectrometry (AMS). About 30% of a given amount of 14C-labelled triolein was catabolized rapidly, while the remaining 70% had a very slow turnover. The study shows the potentia...

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Bibliographic Details
Published in:Applied radiation and isotopes 1996-04, Vol.47 (4), p.417-422
Main Authors: Stenström, K, Leide-Svegborn, S, Erlandsson, B, Hellborg, R, Mattsson, S, Nilsson, L E, Nosslin, B, Skog, G, Wiebert, A
Format: Article
Language:English
Subjects:
Adult
Carbon Dioxide - analysis
Carbon Radioisotopes
Dietary Fats
Humans
Lipid Metabolism
Male
Mass Spectrometry - methods
Middle Aged
Time Factors
Triolein - metabolism
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Summary:Long-term measurements of 14C in CO2 expired after ingestion of 14C-labelled triolein were performed using accelerator mass spectrometry (AMS). About 30% of a given amount of 14C-labelled triolein was catabolized rapidly, while the remaining 70% had a very slow turnover. The study shows the potential of the AMS technique for the study of the long-term biokinetics of 14C-labelled pharmaceuticals. The AMS technique allows the administered activity to be reduced by several orders of magnitude without compromising the study. It may also allow studies of rare drug metabolites.
ISSN:0969-8043
DOI:10.1016/0969-8043(96)82298-6