Parasite-Specific Isotype and Subclass Antibody Profiles during Acute Prepatent Human Schistosomiasis

Increases in anti-schistosomal IgM above IgG Ab levels were observed in recently infected schistosomiasis patients. Several studies have reported on the levels and biological role of IgG subclasses during schistosomiasis. Moreover, Evengard et al. (1990) described the early serum Ab responses of six...

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Bibliographic Details
Published in:Experimental parasitology 1996-03, Vol.82 (2), p.222-224
Main Authors: Shaheen, Hind, Shalaby, Kamal, Farid, Zoheir, Campbell, James, Kamal, Karim
Format: Article
Language:English
Subjects:
Acute Disease
Adolescent
Adult
Animals
Antibodies, Helminth - biosynthesis
Antigens, Helminth - immunology
Biological and medical sciences
Child
Chronic Disease
Diagnosis, Differential
Diseases caused by trematodes
Enzyme-Linked Immunosorbent Assay
Helminthic diseases
Humans
Immunoblotting
Immunoglobulins - biosynthesis
Infectious diseases
Male
Medical sciences
Parasitic diseases
Schistosoma mansoni
Schistosoma mansoni - immunology
Schistosomiases
Schistosomiasis mansoni - diagnosis
Schistosomiasis mansoni - immunology
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Summary:Increases in anti-schistosomal IgM above IgG Ab levels were observed in recently infected schistosomiasis patients. Several studies have reported on the levels and biological role of IgG subclasses during schistosomiasis. Moreover, Evengard et al. (1990) described the early serum Ab responses of six Swedish patients, 6-60 weeks after exposure and Praziquantel treatment. To our knowledge, the present communication describes the first study documenting the humoral responses during human Schistosoma mansoni infection prior to detection of eggs in the feces (prepatent period).
ISSN:0014-4894
1090-2449
DOI:10.1006/expr.1996.0028