Assays for insulin-like growth factors and their binding proteins: Practicalities and pitfalls

Insulin-like growth factors (IGFs) are growth hormone-dependent anabolic peptides that circulate in biologic fluids complexed to a family of IGF binding proteins. Measurement of the serum concentrations of IGF peptides and IGF binding proteins has proved to be an effective means of evaluating functi...

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Bibliographic Details
Published in:The Journal of pediatrics 1996-05, Vol.128 (5), p.S52-S57
Main Authors: Rosenfeld, Ron G., Gargosky, Sharron E.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blotting, Western
Endocrinology
Enzyme-Linked Immunosorbent Assay
Growth Disorders - diagnosis
Growth Disorders - drug therapy
Growth Hormone - deficiency
Growth Hormone-Releasing Hormone - therapeutic use
Humans
Insulin-Like Growth Factor Binding Proteins - blood
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Radioimmunoassay
Somatomedins - analysis
Somatomedins - physiology
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Summary:Insulin-like growth factors (IGFs) are growth hormone-dependent anabolic peptides that circulate in biologic fluids complexed to a family of IGF binding proteins. Measurement of the serum concentrations of IGF peptides and IGF binding proteins has proved to be an effective means of evaluating functional growth hormone status and makes it possible to establish a diagnosis of IGF deficiency. (J P EDIATR 1996;128:S52-7)
ISSN:0022-3476
1097-6833
DOI:10.1016/S0022-3476(96)70012-4