Gender-Related Differences in Left Ventricular Filling Dynamics in Older Subjects After Endurance Exercise Training

• Published in: The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 1996-05, Vol.51A (3), p.B232-B237
• Main Authors: Spina, Robert J., Miller, Tom R., Bogenhagen, William H., Schechtman, Kenneth B., Ehsani, Ali A.
• Format: Article
• Language: English
• Subjects: Aged; Aging - physiology; Cardiac Output; Coronary vessels; Exercise; Exercise - physiology; Female; Heart; Heart Rate; Humans; Male; Middle Aged; Older people; Oxygen Consumption; Physical Endurance; Sex Characteristics; Sexes; Space life sciences; Ventricular Function, Left
• ISSN: 1079-5006; 1758-535X
• DOI: 10.1093/gerona/51A.3.B232

The present study was designed to determine if gender affects the adaptive response to endurance exercise training of left ventricular filling dynamics in older individuals. Recently, it was shown that gender influences the cardiovascular responses to endurance exercise training in older subjects. Older men improve left ventricular systolic performance and increase maximal cardiac output in response to endurance exercise training, whereas older women do not. Twelve men (65 ± 1 years old; mean ± SE) and 10 women (64 ± 1) were studied before and after 9 months of endurance exercise training. Maximal 02 uptake was determined during treadmill exercise. Left ventricular filling dynamics and ejection fraction (EF) at rest and during supine exercise were assessed by Tc-99m radionuclide ventriculography. When expressed relative to body weight, maximal O2 uptake (Vo2 max) was increased by 24% (27.3 ± 1.5 to 34.0 ± 1.5 mllkglmin; p < .01) in men and 27% (21.9 ± 1.0 to 27.8 ±1.0 mllkglmin; p < .01) in women in response to endurance exercise training. In men, the time-to-peak filling rate (TPFR) decreased (−19.8 ± 6.7 ms; p < .05) during exercise at a comparable heart rate in response to training. In contrast, the change in TPFR in women ( + 2.7 ± 6.0 ms) was small and insignificant. Peak filling rate (PFR) at rest and during exercise was similar before and after training in men and women. The change in left ventricular systolic reserve at a comparable heart rate from pre- to posttraining improved in men (ΔEF 4 ± 3%; p < .05), but not in women (−2 ± 3%). The results indicate that the adaptive response of left ventricular filling dynamics to endurance exercise training is influenced by gender in older subjects. Older men show improvement in left ventricular filling dynamics, whereas older women do not.