Localization of an ovarian cancer tumor suppressor gene to a 0.5-cM region between D22S284 and CYP2D, on chromosome 22q

The detection of loss of heterozygosity, indicative of the presence of a tumor suppressor gene, has been reported to occur frequently on chromosome 22q in human ovarian cancer. In this study, 110 sporadic ovarian tumors were analyzed using 8 polymorphic loci to define a minimum region of loss. Fifty...

Full description

Saved in:
Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1996-02, Vol.56 (4), p.719-721
Main Authors: BRYAN, E. J, WATSON, R. H, DAVIS, M, HITCHCOCK, A, FOULKES, W. D, CAMPBELL, I. G
Format: Article
Language:English
Subjects:
Biological and medical sciences
Chromosome Deletion
Chromosome Mapping
Chromosomes, Human, Pair 22
Cytochrome P-450 Enzyme System - genetics
Endometrial Neoplasms - genetics
Endometrial Neoplasms - pathology
Female
Female genital diseases
Genes, Tumor Suppressor
Genetic Markers
Gynecology. Andrology. Obstetrics
Humans
Medical sciences
Neoplasm Staging
Ovarian Neoplasms - classification
Ovarian Neoplasms - genetics
Ovarian Neoplasms - pathology
Polymerase Chain Reaction
Polymorphism, Genetic
Tumors
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The detection of loss of heterozygosity, indicative of the presence of a tumor suppressor gene, has been reported to occur frequently on chromosome 22q in human ovarian cancer. In this study, 110 sporadic ovarian tumors were analyzed using 8 polymorphic loci to define a minimum region of loss. Fifty-eight (53%) tumors showed loss of heterozygosity, and of these 6 exhibited partial loss, enabling the identification of two candidate tumor suppressor gene loci. One region, of less than 0.5 cM, is flanked by D22S284 and CYP2D, and a second region lies distal to D22S276. Analysis of loss of heterozygosity with respect to grade and stage suggests that chromosome 22q loss of heterozygosity is of more relevance in tumor progression rather than initiation.
ISSN:0008-5472
1538-7445