An autoantibody to C1-inhibitor recognizes the reactive center of the inhibitor

An autoantibody to C1-inhibitor produced a clinical disorder resembling that of patients with hereditary angioneurotic edema. The antibody could not interact with C1-inhibitor after exposure to synthetic peptides representing the primary structure of the reactive center region of the protein. Theref...

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Bibliographic Details
Published in:The Journal of laboratory and clinical medicine 1996-02, Vol.127 (2), p.229-232
Main Authors: DONALDSON, V. H, WAGNER, C. J, DAVIS, A. E
Format: Article
Language:English
Subjects:
Allergic diseases
Amino Acid Sequence
Angioedema - genetics
Angioedema - immunology
Autoantibodies
Binding Sites
Biological and medical sciences
Complement C1 Inactivator Proteins - chemistry
Complement C1 Inactivator Proteins - immunology
Humans
Immunoglobulin G
Immunopathology
Medical sciences
Molecular Sequence Data
Other localizations
Peptide Fragments - chemistry
Peptide Fragments - immunology
Peptides - chemical synthesis
Peptides - immunology
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Description
Summary:An autoantibody to C1-inhibitor produced a clinical disorder resembling that of patients with hereditary angioneurotic edema. The antibody could not interact with C1-inhibitor after exposure to synthetic peptides representing the primary structure of the reactive center region of the protein. Therefore the antibody recognized this domain of the inhibitor, and it probably impaired the function of C1-inhibitor by altering its conformational properties.
ISSN:0022-2143
1532-6543
DOI:10.1016/S0022-2143(96)90083-9