Quantifiable Excess of Bone Resorption in Monoclonal Gammopathy Is an Early Symptom of Malignancy: A Prospective Study of 87 Bone Biopsies

To determine if excessive osteoclastic-mediated bone resorption (BR) is an early tumor-induced event in multiple myeloma (MM), BR was assessed at first presentation on quantitative bone biopsy in 87 individuals evaluated for monoclonal gammopathy of undetermined significance (MGUS) and reinterpreted...

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Bibliographic Details
Published in:Blood 1996-06, Vol.87 (11), p.4762-4769
Main Authors: Bataille, Régis, Chappard, Daniel, Basle, Michel-Félix
Format: Article
Language:English
Subjects:
Anemia - etiology
Biological and medical sciences
Biopsy
Bone Resorption - epidemiology
Bone Resorption - etiology
Bone Resorption - pathology
Disease Progression
Follow-Up Studies
Hematologic and hematopoietic diseases
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
Multiple Myeloma - epidemiology
Multiple Myeloma - pathology
Osteoclasts - pathology
Paraproteinemias - complications
Paraproteinemias - epidemiology
Paraproteinemias - pathology
Prognosis
Prospective Studies
Risk Factors
Citations: Items that cite this one
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Summary:To determine if excessive osteoclastic-mediated bone resorption (BR) is an early tumor-induced event in multiple myeloma (MM), BR was assessed at first presentation on quantitative bone biopsy in 87 individuals evaluated for monoclonal gammopathy of undetermined significance (MGUS) and reinterpreted according to the presenting features and subsequent follow-up evaluation. As a reference population, 48 patients with previously untreated overt MM were evaluated under similar conditions. The median level of BR was significantly higher in 48 overt MM versus 87 MGUS patients (12.2% v 5.1% [normal level, or
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V87.11.4762.bloodjournal87114762