Sodium β-Artelinate—A New Potential Gametocytocide

The water-soluble artemisinin analogue sodium β-artelinate, a fast-acting blood schizontocide, was evaluated for gametocytocidal action against simian malariaPlasmodium cynomolgiB, and a single dose of the compound has been found to be an effective gametocytocide by both oral and intravenous routes....

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Bibliographic Details
Published in:Experimental parasitology 1996-04, Vol.82 (3), p.251-254
Main Authors: Tripathi, Renu, Puri, S.K., Dutta, G.P.
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antimalarials - administration & dosage
Antimalarials - pharmacology
Antimalarials - therapeutic use
Antiparasitic agents
Artemisinins
Biological and medical sciences
Culicidae - parasitology
Injections, Intravenous
Insect Vectors - parasitology
Macaca mulatta
Malaria
Malaria - drug therapy
Medical sciences
Pharmacology. Drug treatments
Plasmodium cynomolgi - drug effects
Plasmodium cynomolgi - isolation & purification
Plasmodium cynomolgiB
Rhesus
Sesquiterpenes - administration & dosage
Sesquiterpenes - pharmacology
Sesquiterpenes - therapeutic use
Sodium β-artelinate
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Summary:The water-soluble artemisinin analogue sodium β-artelinate, a fast-acting blood schizontocide, was evaluated for gametocytocidal action against simian malariaPlasmodium cynomolgiB, and a single dose of the compound has been found to be an effective gametocytocide by both oral and intravenous routes. The compound was able to sterilize the circulating gametocytes in rhesus monkey, resulting in loss of mosquito infectivity and oocyst development in theAnopheles stephensi.However, no sporontocidal action has been observed with this compound.
ISSN:0014-4894
1090-2449
DOI:10.1006/expr.1996.0032