(Alkylamino) piperidine bis(heteroaryl)piperizine analogs are potent, broad-spectrum nonnucleoside reverse transcriptase inhibitors of drug-resistant isolates of human immunodeficiency virus type 1 (HIV-1) and select for drug-resistant variants of HIV-1IIIB with reduced replication phenotypes

• Published in: Journal of Virology 1996-06, Vol.70 (6), p.3698-3705
• Main Authors: Olmsted, R A, Slade, D E, Kopta, L A, Poppe, S M, Poel, T J, Newport, S W, Rank, K B, Biles, C, Morge, R A, Dueweke, T J, Yagi, Y, Romero, D L, Thomas, R C, Sharma, S K, Tarpley, W G
• Format: Article
• Language: English
• Subjects: AIDS/HIV; Antiviral Agents - pharmacology; Blotting, Western; Drug Resistance; HIV Reverse Transcriptase; HIV-1 - drug effects; Humans; Reverse Transcriptase Inhibitors - pharmacology; RNA-Directed DNA Polymerase - metabolism; Structure-Activity Relationship; Virus Replication - drug effects
• ISSN: 0022-538X; 1098-5514
• DOI: 10.1128/jvi.70.6.3698-3705.1996

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