Imaging of Olfactory Neuroblastoma by In-111 Bleomycin Complex

No other successful nuclear method, besides bone scanning, has been reported in the literature for in vivo imaging of olfactory neuroblastoma. In this article, excellent uptake is reported by an In-111 labeled bleomycin complex (BLMC) in the ethmoid region of a histologically confirmed olfactory neu...

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Bibliographic Details
Published in:Clinical nuclear medicine 1996-02, Vol.21 (2), p.129-131
Main Authors: JEKUNEN, ANTTI P, KAIREMO, KALEVI J.A, RAMSAY, HANS A, KAJANTI, MIKAEL J
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Bleomycin - analogs & derivatives
Esthesioneuroblastoma, Olfactory - diagnostic imaging
Female
Humans
Indium Radioisotopes
Medical sciences
Nasal Cavity - diagnostic imaging
Nose Neoplasms - diagnostic imaging
Organometallic Compounds
Otorhinolaryngology. Stomatology
Radionuclide Imaging
Time Factors
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:No other successful nuclear method, besides bone scanning, has been reported in the literature for in vivo imaging of olfactory neuroblastoma. In this article, excellent uptake is reported by an In-111 labeled bleomycin complex (BLMC) in the ethmoid region of a histologically confirmed olfactory neuroblastoma. The uptake of BLMC was 0.7 × 10% ID/g at 48 hours after injection, and tumor-to-muscle and tumor-to-fat ratios were 6:1 and 11:1, respectively. The authors conclude that BLMC should be considered as a useful imaging agent, and that BLMC has potential as a radiochemotherapeutic agent against an olfactory neuroblastoma.
ISSN:0363-9762
1536-0229
DOI:10.1097/00003072-199602000-00011