Reference range of prostate-specific antigen after transurethral resection of the prostate

• Published in: Urology (Ridgewood, N.J.) N.J.), 1996-04, Vol.47 (4), p.529-531
• Main Authors: Aus, Gunnar, Bergdahl, Svante, Frösing, Roland, Lodding, Pär, Pileblad, Erik, Hugosson, Jonas
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Biological and medical sciences; Humans; Male; Medical sciences; Middle Aged; Prostate-Specific Antigen - blood; Prostatectomy; Prostatic Hyperplasia - blood; Prostatic Hyperplasia - surgery; Reference Values; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the urinary system
• ISSN: 0090-4295; 1527-9995
• DOI: 10.1016/S0090-4295(99)80489-0

Abstract The aim of the present study was to investigate how transurethral resection of the prostate (TURP) affected the serum levels of prostate-specific antigen (PSA) and to establish reference ranges of PSA in patients who have undergone TURP. PSA was determined preoperatively and 3 months postoperatively in 190 patients who underwent TURP because of benign prostatic hyperplasia (BPH). Mean PSA levels were reduced by 70%, from 6.0 to 1.9 ng/mL Prostate volume was reduced by 58% from 63.3 to 26.5 cc, which is close to the reported normal volume in men without BPH. Ninety percent of the patients had a postoperative PSA value of less than 4 ng/mL and 98% less than 10 ng/mL After a complete TURP with a benign histopathologic specimen, PSA should be expected to be within the normal reference range, that is, less than 4 ng/mL.