Ultrastructural analysis of the adjacent epithelium of oral squamous cell carcinoma

Fifteen biopsies of the immediate adjacent epithelium of oral squamous cell carcinoma were examined under light and electron microscopy. Light microscopic examination of one micron thick sections revealed that the majority of lesions (67%) had hyperplastic or mildly dysppaasic epithelium while the r...

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Bibliographic Details
Published in:British journal of oral & maxillofacial surgery 1996-02, Vol.34 (1), p.51-57
Main Authors: Kannan, S., Balaram, Prabha, Jagadeesh Chandran, G., Radhakrishna Pillai, M., Raveendran Pillai, K., Nalinakumari, K.R., Krishnan Nair, M., Kartha, C.C.
Format: Article
Language:English
Subjects:
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - ultrastructure
Carcinoma, Verrucous - pathology
Carcinoma, Verrucous - ultrastructure
Cell Nucleus - pathology
Cell Nucleus - ultrastructure
Dentistry
Desmosomes
Epithelium - pathology
Epithelium - ultrastructure
Humans
Hyperplasia - pathology
Mouth Mucosa - pathology
Mouth Mucosa - ultrastructure
Mouth Neoplasms - pathology
Mouth Neoplasms - ultrastructure
Neoplasm Invasiveness - pathology
Neoplasm Invasiveness - ultrastructure
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Summary:Fifteen biopsies of the immediate adjacent epithelium of oral squamous cell carcinoma were examined under light and electron microscopy. Light microscopic examination of one micron thick sections revealed that the majority of lesions (67%) had hyperplastic or mildly dysppaasic epithelium while the remaining (33%) had moderate to severe dysplasia. Ultrastructural observations showed that all these lesions had subcellular alterations similar to those seen in frank malignant oral tissue, particularly in the lower half of the epithelium. Important ultrastructural changes observed included bizarre nuclei of basal and lower spinal cells, enlarged and multiple nucleoli, presence of interchromatin and perichromatin granules, loss of desmosomes and marked spongiosis as well as disturbed cellular maturation sequences in the keratinocytes evidenced by abnormal and irregular distribution of maturation markers such as keratohyalin granules and tonotilaments. The present study thus shows the value of electron microscopy in the detection of malignant changes in the adjacent epithelium of oral squamous cell carcinoma.
ISSN:0266-4356
1532-1940
DOI:10.1016/S0266-4356(96)90136-9