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HIV Inhibitory Natural Products. 26. Quinoline Alkaloids from Euodia roxburghiana
Bioassay-directed fractionation of the CH2Cl2−MeOH extract of Euodia roxburghiana resulted in the isolation of two known quinoline alkaloids, buchapine (1) and 2, and three new furoquinoline alkaloids, roxiamines A, B, and C (3−5). Compounds 1 and 2 protected CEM-SS cells from the cytopathic effects...
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| Published in: | Journal of natural products (Washington, D.C.) D.C.), 1996-05, Vol.59 (5), p.469-471 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-a443t-f9c306bc40db179b4c136ed5da731bdc8d076e726c9286adcfe682438b1a6e1b3 |
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| cites | cdi_FETCH-LOGICAL-a443t-f9c306bc40db179b4c136ed5da731bdc8d076e726c9286adcfe682438b1a6e1b3 |
| container_end_page | 471 |
| container_issue | 5 |
| container_start_page | 469 |
| container_title | Journal of natural products (Washington, D.C.) |
| container_volume | 59 |
| creator | McCormick, Jinping L McKee, Tawnya C Cardellina, John H Boyd, Michael R |
| description | Bioassay-directed fractionation of the CH2Cl2−MeOH extract of Euodia roxburghiana resulted in the isolation of two known quinoline alkaloids, buchapine (1) and 2, and three new furoquinoline alkaloids, roxiamines A, B, and C (3−5). Compounds 1 and 2 protected CEM-SS cells from the cytopathic effects of HIV-1 in vitro (EC50 0.94 and 1.64 μM, respectively), but 3−5 were inactive against HIV-1. |
| doi_str_mv | 10.1021/np960250m |
| format | article |
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Quinoline Alkaloids from Euodia roxburghiana</title><source>American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)</source><creator>McCormick, Jinping L ; McKee, Tawnya C ; Cardellina, John H ; Boyd, Michael R</creator><creatorcontrib>McCormick, Jinping L ; McKee, Tawnya C ; Cardellina, John H ; Boyd, Michael R</creatorcontrib><description>Bioassay-directed fractionation of the CH2Cl2−MeOH extract of Euodia roxburghiana resulted in the isolation of two known quinoline alkaloids, buchapine (1) and 2, and three new furoquinoline alkaloids, roxiamines A, B, and C (3−5). Compounds 1 and 2 protected CEM-SS cells from the cytopathic effects of HIV-1 in vitro (EC50 0.94 and 1.64 μM, respectively), but 3−5 were inactive against HIV-1.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np960250m</identifier><identifier>PMID: 8778237</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>AIDS/HIV ; Alkaloids - chemistry ; Alkaloids - isolation & purification ; Alkaloids - pharmacology ; Antiviral Agents - chemistry ; Antiviral Agents - pharmacology ; Biological and medical sciences ; Cells, Cultured ; General pharmacology ; HIV-1 - drug effects ; Humans ; Lymphocytes - drug effects ; Lymphocytes - virology ; Magnetic Resonance Spectroscopy ; Medical sciences ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Extracts - analysis ; Plants, Medicinal - chemistry ; Queensland ; Quinolines - chemistry ; Quinolines - isolation & purification ; Quinolines - pharmacology ; Spectrophotometry, Ultraviolet</subject><ispartof>Journal of natural products (Washington, D.C.), 1996-05, Vol.59 (5), p.469-471</ispartof><rights>Copyright © 1996 American Chemical Society and American Society of Pharmacognosy</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a443t-f9c306bc40db179b4c136ed5da731bdc8d076e726c9286adcfe682438b1a6e1b3</citedby><cites>FETCH-LOGICAL-a443t-f9c306bc40db179b4c136ed5da731bdc8d076e726c9286adcfe682438b1a6e1b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3093132$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8778237$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McCormick, Jinping L</creatorcontrib><creatorcontrib>McKee, Tawnya C</creatorcontrib><creatorcontrib>Cardellina, John H</creatorcontrib><creatorcontrib>Boyd, Michael R</creatorcontrib><title>HIV Inhibitory Natural Products. 26. Quinoline Alkaloids from Euodia roxburghiana</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>Bioassay-directed fractionation of the CH2Cl2−MeOH extract of Euodia roxburghiana resulted in the isolation of two known quinoline alkaloids, buchapine (1) and 2, and three new furoquinoline alkaloids, roxiamines A, B, and C (3−5). Compounds 1 and 2 protected CEM-SS cells from the cytopathic effects of HIV-1 in vitro (EC50 0.94 and 1.64 μM, respectively), but 3−5 were inactive against HIV-1.</description><subject>AIDS/HIV</subject><subject>Alkaloids - chemistry</subject><subject>Alkaloids - isolation & purification</subject><subject>Alkaloids - pharmacology</subject><subject>Antiviral Agents - chemistry</subject><subject>Antiviral Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>General pharmacology</subject><subject>HIV-1 - drug effects</subject><subject>Humans</subject><subject>Lymphocytes - drug effects</subject><subject>Lymphocytes - virology</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Extracts - analysis</subject><subject>Plants, Medicinal - chemistry</subject><subject>Queensland</subject><subject>Quinolines - chemistry</subject><subject>Quinolines - isolation & purification</subject><subject>Quinolines - pharmacology</subject><subject>Spectrophotometry, Ultraviolet</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNptkEtr3DAUhUVpSadJF_0BBS3aQhee6mFL9jIZknggpAlJW-hGXD3cKLGtqWRB8u_jMMOssrpczsfh8CH0iZIlJYz-GDeNIKwiwxu0oBUjxcv3Fi0IFbzgtSjfow8p3RNCOGmqA3RQS1kzLhfoul3_xuvxzms_hfiEL2HKEXp8FYPNZkpLzMQSX2c_ht6PDh_3D9AHbxPuYhjwaQ7WA47hUef4787DCEfoXQd9ch939xD9Oju9XbXFxc_z9er4ooCy5FPRNYYToU1JrKay0aWhXDhbWZCcamtqS6RwkgnTsFqANZ0TNSt5rSkIRzU_RN-2vZsY_meXJjX4ZFzfw-hCTkrWpGwqIWfw-xY0MaQUXac20Q8QnxQl6kWf2uub2c-70qwHZ_fkztecf9nlkAz0XYTR-LTHZruccjZjxRbzaXKP-xjig5oHyUrdXt2o9mT15-95K1Q781-3PJik7kOO42zulXnPZaySFg</recordid><startdate>19960501</startdate><enddate>19960501</enddate><creator>McCormick, Jinping L</creator><creator>McKee, Tawnya C</creator><creator>Cardellina, John H</creator><creator>Boyd, Michael R</creator><general>American Chemical Society</general><general>American Society of Pharmacognosy</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960501</creationdate><title>HIV Inhibitory Natural Products. 26. Quinoline Alkaloids from Euodia roxburghiana</title><author>McCormick, Jinping L ; McKee, Tawnya C ; Cardellina, John H ; Boyd, Michael R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a443t-f9c306bc40db179b4c136ed5da731bdc8d076e726c9286adcfe682438b1a6e1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>AIDS/HIV</topic><topic>Alkaloids - chemistry</topic><topic>Alkaloids - isolation & purification</topic><topic>Alkaloids - pharmacology</topic><topic>Antiviral Agents - chemistry</topic><topic>Antiviral Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>General pharmacology</topic><topic>HIV-1 - drug effects</topic><topic>Humans</topic><topic>Lymphocytes - drug effects</topic><topic>Lymphocytes - virology</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Extracts - analysis</topic><topic>Plants, Medicinal - chemistry</topic><topic>Queensland</topic><topic>Quinolines - chemistry</topic><topic>Quinolines - isolation & purification</topic><topic>Quinolines - pharmacology</topic><topic>Spectrophotometry, Ultraviolet</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McCormick, Jinping L</creatorcontrib><creatorcontrib>McKee, Tawnya C</creatorcontrib><creatorcontrib>Cardellina, John H</creatorcontrib><creatorcontrib>Boyd, Michael R</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McCormick, Jinping L</au><au>McKee, Tawnya C</au><au>Cardellina, John H</au><au>Boyd, Michael R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HIV Inhibitory Natural Products. 26. Quinoline Alkaloids from Euodia roxburghiana</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>1996-05-01</date><risdate>1996</risdate><volume>59</volume><issue>5</issue><spage>469</spage><epage>471</epage><pages>469-471</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract>Bioassay-directed fractionation of the CH2Cl2−MeOH extract of Euodia roxburghiana resulted in the isolation of two known quinoline alkaloids, buchapine (1) and 2, and three new furoquinoline alkaloids, roxiamines A, B, and C (3−5). Compounds 1 and 2 protected CEM-SS cells from the cytopathic effects of HIV-1 in vitro (EC50 0.94 and 1.64 μM, respectively), but 3−5 were inactive against HIV-1.</abstract><cop>Washington, DC</cop><cop>Glendale, AZ</cop><pub>American Chemical Society</pub><pmid>8778237</pmid><doi>10.1021/np960250m</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Washington, D.C.), 1996-05, Vol.59 (5), p.469-471 |
| issn | 0163-3864 1520-6025 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78049567 |
| source | American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list) |
| subjects | AIDS/HIV Alkaloids - chemistry Alkaloids - isolation & purification Alkaloids - pharmacology Antiviral Agents - chemistry Antiviral Agents - pharmacology Biological and medical sciences Cells, Cultured General pharmacology HIV-1 - drug effects Humans Lymphocytes - drug effects Lymphocytes - virology Magnetic Resonance Spectroscopy Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - analysis Plants, Medicinal - chemistry Queensland Quinolines - chemistry Quinolines - isolation & purification Quinolines - pharmacology Spectrophotometry, Ultraviolet |
| title | HIV Inhibitory Natural Products. 26. Quinoline Alkaloids from Euodia roxburghiana |
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