Interleukin-6 (IL-6) in patients with Behçet's disease

We have examined the levels of interleukin-6 (IL-6) in plasma and supernatants of peripheral blood mononuclear cells (PBMC) from patients with Behçet's disease and healthy controls using a sensitive enzyme-linked immunosorbent assay (ELISA). Plasma IL-6 level was not detected in any subjects. T...

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Bibliographic Details
Published in:Journal of dermatological science 1996-03, Vol.11 (3), p.189-195
Main Authors: Yamakawa, Yuko, Sugita, Yasuyuki, Nagatani, Tetsuo, Takahashi, Sanami, Yamakawa, Tadashi, Tanaka, Shun-ichi, Nakamura, Satoshi, Ohno, Shigeaki, Sekihara, Hisahiko, Okuda, Kenji, Nakajima, Hiroshi
Format: Article
Language:English
Subjects:
Adult
Base Sequence
Behcet Syndrome - blood
Behcet Syndrome - immunology
Behçet's disease
Cells, Cultured
ELISA
Female
Humans
Interleukin-6
Interleukin-6 - blood
Interleukin-6 - genetics
Interleukin-6 - metabolism
Leukocytes, Mononuclear - metabolism
Male
Middle Aged
Molecular Sequence Data
Northern blotting
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Summary:We have examined the levels of interleukin-6 (IL-6) in plasma and supernatants of peripheral blood mononuclear cells (PBMC) from patients with Behçet's disease and healthy controls using a sensitive enzyme-linked immunosorbent assay (ELISA). Plasma IL-6 level was not detected in any subjects. The IL-6 concentrations in culture supernatants of patients with active Behçet's disease were significantly high compared with patients with inactive disease and healthy controls. Moreover, we investigated IL-6 gene expression in cultured PBMC from patients with Behçet's disease. IL-6 gene expression was enhanced in active patients compared with inactive patients. These results show that IL-6 may play a role in the pathogenesis of Behçet's disease.
ISSN:0923-1811
1873-569X
DOI:10.1016/0923-1811(95)00439-4