Effects of praziquantel on experimental Schistosoma bovis infection in goats

The effect of praziquantel against experimental Schistosoma bovis infection in West African Dwarf goats was investigated. Thirty goats were exposed to 2000 cercariae each and 15 of those received a praziquantel treatment (60 mg kg −1) 13 weeks post-infection. One day, 1 week and 4 weeks post-treatme...

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Bibliographic Details
Published in:Veterinary parasitology 1996-03, Vol.62 (1), p.83-91
Main Authors: Johansen, Maria V., Monrad, Jesper, Ø. Christensen, Niels
Format: Article
Language:English
Subjects:
Animals
Antiplatyhelmintic Agents - therapeutic use
Control methods-Trematoda
Drug efficacy
Feces - parasitology
Female
Goat
Goats
Male
Orchiectomy
Parasite Egg Count
Praziquantel
Praziquantel - therapeutic use
Schistosoma - growth & development
Schistosoma - isolation & purification
Schistosoma bovis
Schistosomiasis - drug therapy
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Summary:The effect of praziquantel against experimental Schistosoma bovis infection in West African Dwarf goats was investigated. Thirty goats were exposed to 2000 cercariae each and 15 of those received a praziquantel treatment (60 mg kg −1) 13 weeks post-infection. One day, 1 week and 4 weeks post-treatment representative goats from each group were killed and worms were recovered by perfusion. For comparison, parasite-free control animals were monitored, some of which were given praziquantel. Every second week during the study, faecal samples were collected. The cure rate was 100% 1 day, 99.4% 1 week and 95.7% 4 weeks post-treatment. Tissue egg counts were significantly reduced ( P
ISSN:0304-4017
1873-2550
DOI:10.1016/0304-4017(95)00849-7