A New Approach to the Treatment of Experimental Septic Shock

Previous work has shown that disseminated intravascular coagulation (DIC) may produce multiple organ failure, including adult respiratory distress syndrome, by obstruction of visceral micro circulation by microclots. DIC can be produced by sepsis. This study tests the ability of a plasminogen activa...

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Bibliographic Details
Published in:The Journal of surgical research 1996-03, Vol.61 (2), p.311-316
Main Authors: Hardaway, Robert M., Williams, Charles H., Sun, Yang
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
Cardiac Output
Disseminated Intravascular Coagulation - prevention & control
Escherichia coli Infections - therapy
Fibrinogen - analysis
Hydrogen-Ion Concentration
Medical sciences
Pharmacology. Drug treatments
Plasminogen Activators - therapeutic use
Shock, Septic - blood
Shock, Septic - physiopathology
Shock, Septic - therapy
Swine
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Summary:Previous work has shown that disseminated intravascular coagulation (DIC) may produce multiple organ failure, including adult respiratory distress syndrome, by obstruction of visceral micro circulation by microclots. DIC can be produced by sepsis. This study tests the ability of a plasminogen activator to prevent death from an intravenous injection of killedEscherichia coliby causing lysis of the microclots. Subjects were two groups of 8 pigs each with body weight of 60–70 lbs. KilledEscherichia coliwere injected IV in 16 pigs. Invasive monitoring was used to record physiologic data during the 5.0-hr experimental period. Urokinase injected 20 min after the injection ofEscherichia coliorganisms significantly prevented mortality, acidosis, and development of blood incoagula- bility. We conclude that plasminogen activator can significantly prevent fatalEscherichia coli(septic) shock without causing bleeding.
ISSN:0022-4804
1095-8673
DOI:10.1006/jsre.1996.0122