Cloning of the Human Homologue of the TGFβ-Stimulated Clone 22 Gene

We have isolated the human homologue of the TGFβ-stimulated clone 22 gene from a human embryo cDNA library. This gene maps to the q14 region of chromosome 13. Its deduced amino acid sequence is almost 99% identical to that of mouse or rat proteins and includes a putative leucine zipper motif. An abu...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 1996-05, Vol.222 (3), p.821-826
Main Authors: Jay, Philippe, Ji, Jing Wei, Marsollier, Catherine, Taviaux, Sylvie, Bergé-Lefranc, Jean-Louis, Berta, Philippe
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 13
Cloning, Molecular
DNA, Complementary - genetics
Gene Expression
Genes, Immediate-Early
Humans
Mice
Molecular Sequence Data
Proteins - genetics
Rats
Repressor Proteins
RNA, Messenger - genetics
Sequence Alignment
Sequence Homology, Amino Acid
Swine
Transforming Growth Factor beta - pharmacology
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Summary:We have isolated the human homologue of the TGFβ-stimulated clone 22 gene from a human embryo cDNA library. This gene maps to the q14 region of chromosome 13. Its deduced amino acid sequence is almost 99% identical to that of mouse or rat proteins and includes a putative leucine zipper motif. An abundant major transcript of 1.8 kb and in some instances an additional 5 kb transcript were detected by Northern blotting of several human tissues. The TSC-22 protein has been shown to be well conserved across evolution as evidenced by the existence of a Drosophila homologue. These observations prompt discussion on the strong conservation of TSC-22 during evolution but also on its general function as a primary response gene expressed either when stimulated by several different factors during early human development, or in the adult in response to inducing differentiation signals.
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.1996.0825