Reversible vasoconstriction in rats with congenital unilateral hydronephrosis

We studied the effects of inhibition of either prostaglandins or the role of prostanoids and the renin-angiotensin system on renal function in rats with congenital unilateral hydronephrosis. Wistar rats with congenital unilateral hydronephrosis were infused with normal saline (control), captopril di...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 1987-07, Vol.1 (3), p.498-501
Main Authors: Boineau, F G, Vari, R C, Lewy, J E
Format: Article
Language:English
Subjects:
Animals
Glomerular Filtration Rate
Hydronephrosis - congenital
Hydronephrosis - physiopathology
Male
Rats
Rats, Inbred Strains
Vasoconstriction - physiology
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Summary:We studied the effects of inhibition of either prostaglandins or the role of prostanoids and the renin-angiotensin system on renal function in rats with congenital unilateral hydronephrosis. Wistar rats with congenital unilateral hydronephrosis were infused with normal saline (control), captopril dissolved in normal saline or indomethacin dissolved in a solution of sodium chloride and sodium carbonate. In the control group both glomerular filtration rate (GFR) and effective renal plasma flow were reduced in the right hydronephrotic kidney (RHK) compared with the normal left kidney. Indomethacin did not improve renal function in the RHK. Captopril significantly improved GFR in the RHK. These results support the conclusion that the renin-angiotensin system is an important mediator of reduced GFR in congenital unilateral hydronephrosis in rats.
ISSN:0931-041X
1432-198X
DOI:10.1007/BF00849260