Influence of pH on the Release of Propranolol Hydrochloride from Matrices Containing Hydroxypropylmethylcellulose K4M and Carbopol 974

The dissolution of propranolol hydrochloride from matrices containing hydroxypropylmethylcellulose K4M (HPMC K4M) and carbopol 974 has been investigated using 0.1M hydrochloric acid or phosphate buffer at pH 4.5 or pH 7.5. In 0.1M hydrochloric acid, HPMC K4M predominantly controlled release since ca...

Full description

Saved in:
Bibliographic Details
Published in:Journal of pharmaceutical sciences 1996-03, Vol.85 (3), p.330-334
Main Authors: Perez-Marcos, Belen, Ford, James L., Armstrong, David J., Elliott, Peter N.C., Rostron, Christopher, Hogan, John E.
Format: Article
Language:English
Subjects:
Acrylic Resins
Biological and medical sciences
General pharmacology
Hydrogen-Ion Concentration
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polymers - chemistry
Polyvinyls - chemistry
Propranolol - chemistry
Protease Inhibitors - chemistry
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The dissolution of propranolol hydrochloride from matrices containing hydroxypropylmethylcellulose K4M (HPMC K4M) and carbopol 974 has been investigated using 0.1M hydrochloric acid or phosphate buffer at pH 4.5 or pH 7.5. In 0.1M hydrochloric acid, HPMC K4M predominantly controlled release since carbopol has a low solubility at this pH. As the pH increased, the carbopol became increasingly ionized and interacted with propranolol hydrochloride to form an insoluble complex which retarded the release of the drug. In addition, the nature of the interaction between carbopol 974 and HPMC K4M altered. DSC and viscometric studies indicated that the two polymers contributed synergisti-cally to the gel network at pH 7.5. Thus at pH 7.5 both polymers contributed to matrix integrity and to the control of drug release.
ISSN:0022-3549
1520-6017
DOI:10.1021/js950359z