The influence of drugs on nasal ciliary movement

Drugs in nasal preparations, for local use as well as for systemic use, should not interfere with the self-cleaning capacity of the nose, effectuated by the ciliary epithelium. Many drugs and additives, however, have a negative effect on nasal ciliary function. Examples of ciliotoxic agents are lipo...

Full description

Saved in:
Bibliographic Details
Published in:Pharmaceutical research 1987-12, Vol.4 (6), p.445-449
Main Authors: HERMENS, W. A. J. J, MERKUS, F. W. H. M
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cilia - drug effects
General pharmacology
Humans
Medical sciences
Nasal Mucosa - drug effects
Pharmaceutical technology. Pharmaceutical industry
Pharmacology
Pharmacology. Drug treatments
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Drugs in nasal preparations, for local use as well as for systemic use, should not interfere with the self-cleaning capacity of the nose, effectuated by the ciliary epithelium. Many drugs and additives, however, have a negative effect on nasal ciliary function. Examples of ciliotoxic agents are lipophilic and mercuric preservatives, local anesthetics, antihistamines, propranolol, and absorption enhancers such as the bile salts. Cholinergic drugs and beta-adrenergic drugs exert a ciliostimulatory effect. It is the purpose of this review to summarize the present knowledge of ciliotoxicity of drugs and additives and to give recommendations for the use of ciliofriendly drugs in nasal preparations.
ISSN:0724-8741
1573-904X
DOI:10.1023/A:1016463118748