Element- and isotope-specific detection for high-performance liquid chromatography using chemical reaction interface mass spectrometry

We have developed a combination of high-performance liquid chromatography (HPLC) and the chemical reaction interface mass spectrometry (CRIMS) method by using a Vestec Universal Interface (UI). This interface provides the extremely high degree of solvent removal that the CRIMS process requires. In d...

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Bibliographic Details
Published in:Journal of Chromatography A 1996-05, Vol.732 (2), p.189-199
Main Authors: McLean, Matt, Vestal, Marvin L., Teffera, Yohannes, Abramson, Fred P.
Format: Article
Language:English
Subjects:
Chemical reaction interface mass spectrometry
Chromatography, High Pressure Liquid - methods
Detection, LC
Element-specific detection
Isotope-specific detection
Mass spectrometry
Mass Spectrometry - methods
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Summary:We have developed a combination of high-performance liquid chromatography (HPLC) and the chemical reaction interface mass spectrometry (CRIMS) method by using a Vestec Universal Interface (UI). This interface provides the extremely high degree of solvent removal that the CRIMS process requires. In doing so, we have produced an HPLC detector with the ability to carry out element- and isotope-selective analyses with detection that is inherently: linear, structure-independent, sensitive, selective, comprehensive and flexible. The characteristics of the instrumentation and its performance are described.
ISSN:0021-9673
DOI:10.1016/0021-9673(95)01279-6