Clinical comparison of three labeled-antibody immunoassays of free triiodothyronine

Three labeled-antibody immunoassays of free triiodothyronine (FT3) were studied in hyperthyroid patients, patients with nonthyroidal illness, and patients being treated with amiodarone; we also studied sera presenting known interferences (n for all groups = 465). The results were compared with those...

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Bibliographic Details
Published in:Clinical chemistry (Baltimore, Md.) Md.), 1996-06, Vol.42 (6), p.933-941
Main Authors: Piketty, ML, d'Herbomez, M, Le Guillouzic, D, Lebtahi, R, Cosson, E, Dumont, A, Dilouya, A, Helal, BO
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Amiodarone - therapeutic use
Autoanalysis - statistics & numerical data
Autoantibodies - blood
Biological and medical sciences
Endocrinology
Humans
Hyperthyroidism - blood
Immunoassay - methods
Immunoassay - statistics & numerical data
Investigative techniques, diagnostic techniques (general aspects)
Kidney Failure, Chronic - blood
Medical sciences
Middle Aged
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Quality Control
Reference Values
Sensitivity and Specificity
Thyroxine - immunology
Triiodothyronine - blood
Triiodothyronine - immunology
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Summary:Three labeled-antibody immunoassays of free triiodothyronine (FT3) were studied in hyperthyroid patients, patients with nonthyroidal illness, and patients being treated with amiodarone; we also studied sera presenting known interferences (n for all groups = 465). The results were compared with those of a one-step labeled-analog assay. The precision of the two automated assays were similar to that of the manual assays. The three labeled-antibody FT3 assays demonstrated a satisfactory diagnostic performance for confirming hyperthyroidism and robustness to interference; nevertheless, two assays displayed unusual behavior in some patients with nonthyroidal illness, with chronic renal failure, or after amiodarone therapy.
ISSN:0009-9147
1530-8561
DOI:10.1093/clinchem/42.6.933