Molecular cloning of a feline leukemia virus that induces fatal immunodeficiency disease in cats

A replication-defective variant of feline leukemia virus was molecularly cloned directly from infected tissue and found to induce a rapid and fatal immunodeficiency syndrome in cats. Studies with cloned viruses also showed that subtle mutational changes would convert a minimally pathogenic virus int...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1988-02, Vol.239 (4842), p.906-910
Main Authors: Overbaugh, J, Donahue, P.R, Quackenbush, S.L, Hoover, E.A, Mullins, J.I
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome
AIDS
AIDS/HIV
Amino Acid Sequence
Animals
Base Sequence
BIOLOGIA MOLECULAR
Biological and medical sciences
BIOLOGIE MOLECULAIRE
Bone Marrow - microbiology
CATS
Cell lines
CHAT
CLONACION
CLONAGE
CLONING
Cloning, Molecular
DNA
DNA, Viral - genetics
ENFERMEDADES INMUNOLOGICAS
Experimental and animal immunopathology. Animal models
Feline leukemia virus
FETO
FOETUS
GATO
Genetics
Genomes
Humans
Immunologic deficiency syndromes
Immunologic Deficiency Syndromes - etiology
Immunologic Deficiency Syndromes - microbiology
Immunological deficiency syndromes
IMMUNOLOGICAL DISEASES
Immunopathology
LEUCEMIA
LEUCEMIE
LEUKAEMIA
Leukemia
Leukemia Virus, Feline - genetics
Leukemia Virus, Feline - pathogenicity
MALADIE IMMUNOLOGIQUE
Medical sciences
MOLECULAR BIOLOGY
Molecular Sequence Data
Mutation
Physiological immunosuppression
Polymorphism, Restriction Fragment Length
RETROVIRIDAE
Retroviruses
T lymphocytes
Transfection
Viral diseases
Virus Replication
Viruses
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Description
Summary:A replication-defective variant of feline leukemia virus was molecularly cloned directly from infected tissue and found to induce a rapid and fatal immunodeficiency syndrome in cats. Studies with cloned viruses also showed that subtle mutational changes would convert a minimally pathogenic virus into one that would induce an acute form of immunodeficiency. The data suggest that acutely pathogenic viruses may be selected against by current methods for isolation of the human and simian immunodeficiency viruses.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.2893454