Platelet-Derived Growth Factor B-Chain Homodimer Suppressing a Convulsion of Epilepsy Model Mouse El

El mouse is a mutant which has epileptic convulsions after tossing-up stimulations and has a hippocampal dysfunction. Platelet-derived growth factor B-chain homodimer has been reported to be a trophic factor of hippocampal neurons. We found that a recombinant PDGF-BB suppressed the convulsions of El...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 1996-06, Vol.223 (1), p.60-63
Main Authors: Masuda, Yutaka, Miura, Naoyuki, Kawarada, Yoshihiko, Kawagoe, Masami, Shimizu, Tetsuo, Sugiyama, Toshihiro, Hishikawa, Yasuo
Format: Article
Language:English
Subjects:
Animals
Anticonvulsants - pharmacology
Disease Models, Animal
Epilepsy, Tonic-Clonic - genetics
Epilepsy, Tonic-Clonic - prevention & control
Humans
Male
Mice
Mice, Neurologic Mutants
Oligopeptides - pharmacology
Platelet-Derived Growth Factor - pharmacology
Proto-Oncogene Proteins c-sis
Receptors, Thrombin
Recombinant Proteins - pharmacology
Seizures - genetics
Seizures - prevention & control
Thrombin - pharmacology
Time Factors
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Summary:El mouse is a mutant which has epileptic convulsions after tossing-up stimulations and has a hippocampal dysfunction. Platelet-derived growth factor B-chain homodimer has been reported to be a trophic factor of hippocampal neurons. We found that a recombinant PDGF-BB suppressed the convulsions of El mice in a dose-dependent manner. Furthermore, thrombin-treated mice manifested no convulsions, but thrombin receptor activating peptide-treated ones had convulsions. These findings suggest that an abnormality in PDGF-BB release may make El mice susceptible to tonic-clonic convulsions.
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.1996.0846